囊性纤维化儿童家庭空气污染研究

该数据集来自 clinicaltrials.gov,聚焦囊性纤维化(CF)儿童的家庭空气污染暴露问题。CF 是一种严重的慢性肺部疾病,尽管治疗取得进展,仍导致显著发病和死亡

Seattle Children's HospitalSeattle Children's Hospital
clinicaltrials
浏览 13
表格预测Cystic Fibrosis (CF)
Home Air Pollution in Children With Cystic Fibrosis Study

基本信息

模态
表格
任务类型
预测
创建/更新时间
2026-10-12

资源简介

囊性纤维化儿童家庭空气污染研究

该数据集来自 clinicaltrials.gov,聚焦囊性纤维化(CF)儿童的家庭空气污染暴露问题。CF 是一种严重的慢性肺部疾病,尽管治疗取得进展,仍导致显著发病和死亡。西班牙裔 CF 儿童比非西班牙裔白人 CF 儿童预后更差,死亡率更高、肺部疾病更严重,且这一差异在 CFTR 调节剂问世后进一步加剧。非遗传因素(包括环境暴露)估计可解释 CF 肺部疾病严重程度变异的 50%。该数据可用于研究环境暴露与 CF 儿童肺部疾病严重程度之间的关联,并探索健康差异的潜在成因(来源 clinicaltrials.gov)。

【数据内容】

源站描述(机器翻译,仅供参考):条件:囊性纤维化(CF)。囊性纤维化(CF)是一种破坏性的慢性肺部疾病,尽管治疗取得了巨大进展,仍继续导致显著的发病率和死亡率。西班牙裔 CF 儿童比非西班牙裔白人 CF 儿童预后更差,包括死亡率更高和肺部疾病更严重。目前尚不清楚为什么西班牙裔 CF 儿童的疾病更严重,因为 CFTR 遗传严重程度、诊断年龄或社会经济地位都无法解释。自改变疾病的新型疗法 CFTR 调节剂开发以来,西班牙裔 CF 儿童的健康差异恶化而非改善。确定是什么导致西班牙裔 CF 儿童肺部疾病严重程度至关重要。包括环境暴露在内的非遗传因素,估计占 CF 肺部疾病严重程度变异的 50%。

【主题与分类】

主题标签:Cystic Fibrosis (CF)。本站分类:呼吸系统疾病/哮喘。

【获取与许可】

源站页面:https://clinicaltrials.gov/study/NCT07665203

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下载信息

注册下载

需要注册 Kaggle 账号并登录后下载,适合需要跟踪下载记录和使用 API 的用户。

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暂未开放

当前数据集主要来源为 Kaggle 公开托管,完整影像包建议通过原始链接或 Kaggle API 获取。

使用方式

数据集获取

源站:https://clinicaltrials.gov/study/NCT07665203

标准获取流程:

  1. 访问源站链接,注册/登录账号;
  2. 进入数据集详情页,按页面指引申请权限或直接下载;
  3. 部分平台提供 SDK,例如:
    • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
    • ModelScope: pip install modelscope 后 modelscope download
    • 天池: 登录后页面提供直链下载
      以源站「数据下载/使用文档」页面为准。

数据说明

Conditions: Cystic Fibrosis (CF). Cystic Fibrosis (CF) is a devastating chronic pulmonary disease that continues to cause significant morbidity and mortality despite great advances in therapies. Hispanic children with CF have worse outcomes, including higher mortality and more severe pulmonary disease, than non-Hispanic white children with CF. It is not known why Hispanic children with CF have more severe disease as it is not explained by CFTR genetic severity, diagnosis age, or socioeconomic status. The health disparities have worsened, not improved, for Hispanic children with CF since the development of new disease-altering therapeutics, CFTR modulators. It is critical to determine what is contributing to lung disease severity in Hispanic children with CF. Non-genetic factors, including environmental exposures, are estimated to account for 50% of lung disease severity variability in CF. Air pollution exposure during early childhood is associated with lower pulmonary function in healthy children and severe lung disease in children with asthma. However, air pollution exposure is vastly understudied in other chronic pulmonary diseases of childhood, such as CF. Investigating air pollution exposure in CF may provide vital information about the drivers of health disparities in Hispanic children with CF and about the environmental exposures influencing lung disease severity across all children with CF. To investigate air pollution exposure in children with CF, the investigators have assembled a multidisciplinary team of international experts in air pollution exposure, CF lung disease, health disparities, and pulmonary microbiome. The investigators will use two phenomenally rich databases, the CF Foundation Patient Registry and the University of Washington Spatiotemporal Air Pollution Exposure Model, to investigate the first aim: 1A) To determine whether neighborhood-level ambient air pollution exposure during childhood differs between 1500 Hispanic and 8500 non-Hispanic white cwCF in the CF Foundation Pa

数据加载示例(图像类)

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

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