阿尔茨海默病代谢组学联盟 UPenn 研究

数据集获取

源站：https://synapse.org/Synapse:syn9705311

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

###The Alzheimer’s Disease Metabolomics Consortium UPenn (ADMC_UPenn) Study This case–control study examined participants enrolled in a prospective longitudinal study. The participants were recruited at the Penn Memory Center, Alzheimer’s Disease Clinical Center (ADCC), Perelman School of Medicine (PSOM), University of Pennsylvania (Philadelphia, PA, USA) and the Maria de los Santos Health Center (Philadelphia, PA, USA), following written informed consent under approval of the University of Pennsylvania Institutional Review Board. Show More Cases were classified as AD or MCI based on standard diagnostic criteria [1-3] according to procedures established for ADCCs and the National Alzheimer’s Coordinating Center (NACC). From this cohort, we identified a subset of 127 CSF and plasma samples obtained on the same day from 112 unique participants (51 AD, 18 MCI and 43 CN), and other traditional biomarker data. A set of 32 serum samples matching plasma samples as closely as possible for date was collected from a subset of these subjects in order to examine direct serum/plasma comparisons among obtained values. Subjects were selected from the Integrated Neurodegenerative Diseases Database (INDD) of the Center for Neurodegenerative Diseases Research (CNDR) at PSOM under the directorship of John Q. Trojanowski, M.D., Ph.D. using the web-based query tool INQUERY developed at CNDR. Neuropsychological testing was conducted including the Mini-Mental State Exam (MMSE) and/or tests of frontal executive function, memory, language, praxis, visuospatial construction, motor performance, mood and function, based on the NACC Uniform Data Set (UDS) [4-6]. Details for CSF samples collection and for standardized Luminex assay for amyloid-beta (Ab42), total tau (t-tau) and phosphorylated tau (p-tau) at the threonine 181 are available in previous publications [7-9]. Plasma and CSF aliquots (0.5 mL) were retrieved from the UPenn biorepository, were coded to allow assays to be performed withou

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。