人类小胶质细胞转录图谱揭示年龄、性别及 APOE 相关免疫代谢通路扰动

数据集获取

源站：https://synapse.org/Synapse:syn28450881

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

Manuscript: Transcriptional landscape of human microglia implicates age, sex and APOE-related immunometabolic pathway perturbations Authors: Tulsi Patel, Troy P. Carnwath, Xue Wang, Mariet Allen, Sarah J. Lincoln, Laura J. Lewis-Tuffin, Zachary S. Quicksall, Shu Lin, Frederick Q. Tutor-New, Charlotte C.G. Ho, Yuhao Min, Kimberly G. Malphrus, Thuy T. Nguyen, Elizabeth Martin, Cesar A. Garcia, Rawan M. Alkharboosh, Sanjeet Grewal, Kaisorn Chaichana, Robert Wharen, Hugo Guerrero-Cazares, Alfredo Quinones-Hinojosa, Nilüfer Ertekin-Taner Preprint URL: https://www.biorxiv.org/content/10.1101/2021.05.13.444000v1 **Published URL:**https://onlinelibrary.wiley.com/doi/10.1111/acel.13606 Dataset contact: Dr. Mariet Allen, Mayo Clinic @mxa24 — Data use acknowledgement: Please acknowledge the data contributor in publications based on secondary data use by including the following statement and references in your manuscript. >“The results published here are in whole or in part based on data obtained from the AD Knowledge Portal (https://adknowledgeportal.org/). " >MCMPS: The Mayo Clinic Microglial Profiling Study (MCMPS) was led by Dr. Nilüfer Ertekin-Taner at the Mayo Clinic, Jacksonville, FL through a collaborative effort with Dr. Alfredo Quinones-Hinojosa. MCMPS is part of the multi-PI RF1AG051504 (MPIs Bu and Ertekin-Taner) and further supported by NIH funding U01 AG046193, R01 AG051504 (NET) and the Mayo Clinic Investigator Award, State of Florida Cancer Chair and Uihlein Family Support (AQH) using neurosurgical samples from the Mayo Clinic managed and supported by the Neurosurgery Biobank Tissue Repository Team.” Cite: doi:10.1111/acel.13606 >Mayo RNAseq: "The Mayo RNAseq study data was led by Dr. Nilüfer Ertekin-Taner, Mayo Clinic, Jacksonville, FL as part of the multi-PI U01 AG046139 (MPIs Golde, Ertekin-Taner, Younkin, Price). Samples were provided from the following sources: The Mayo Clinic Brain Bank. Data collection was supported t

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。