P3H家族在癌症中的作用：对预后、肿瘤微环境和药物敏感性的影响

数据集获取（Figshare）

• 源站标题：Table_1_The role of P3H family in cancer: implications for prognosis, tumor microenvironment and drug sensitivity.docx
• DOI：10.3389/fonc.2024.1374696.s002
• 发布日期：2024-04-19
• 文件数：1 个
• 文件总体积：700.09 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_The_role_of_P3H_family_in_cancer_implications_for_prognosis_tumor_microenvironment_and_drug_sensitivity_docx/25649646

命令行下载

curl -L -o "Table_1_The role of P3H family in cancer: implications for prognosis, tumor microenvironment and drug sensitivity.docx" "https://ndownloader.figshare.com/files/45749979"

文件清单

• Table_1_The role of P3H family in cancer: implications for prognosis, tumor microenvironment and drug sensitivity.docx（700.09 KB）

文件总体积 700.09 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

IntroductionProlyl 3-hydroxylases (P3H) are crucial enzymes in collagen biosynthesis and are known to be involved in a variety of physiological processes. However, their specific roles in cancer progression, modulation of the tumor microenvironment (TME), and impact on patient prognosis remain areas that require further investigation.
MethodsThe investigation involved a comprehensive analysis of expression profiles and clinical data obtained from the Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases. This included the assessment of genetic variation, gene expression, and the prognostic significance of P3H family genes. P3H scores were calculated using various databases and R-based tools, followed by correlation analyses with the TME, immune cell infiltration, drug sensitivity and immunotherapy.Variations in P3H gene expression patterns were observed across different tumor types and prognoses, suggesting that most genes within the family were risk factors, especially P3H1 and P3H4. The P3H score was associated with immune infiltration and drug resistance. Notably, individuals with elevated expression of P3H2, P3H3, and CRTAP exhibited higher resistance to multiple anti-tumor drugs.
ResultsP3H family proteins play diverse roles in cancer progression, significantly impacting patient prognosis and the effectiveness of immunotherapy.
ConclusionsThe P3H score, identified as a potential biomarker for evaluating TME, holds promise in guiding precision medicine strategies.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fonc.2024.1374696.s002（source: https://frontiersin.figshare.com/articles/dataset/Table_1_The_role_of_P3H_family_in_cancer_implications_for_prognosis_tumor_microenvironment_and_drug_sensitivity_docx/25649646）。