尼曼-皮克病C型中细胞色素P450催化药物代谢缺陷数据集

资源简介

尼曼-皮克病C型中细胞色素P450催化药物代谢缺陷数据集

【数据集背景】

本数据集源站标题为《Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease》。配套论文《Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0152007。源站首次发布：2016-03-28。

【数据内容】

源站原始描述：Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular and organ system dysfunction. The underlying molecular mechanisms that lead to the range of clinical presentations in NPC are not fully understood. While evaluating potential small molecule therapies in Npc1-/- mice, we observed a consistent patt…

【数据结构与技术规格】

文件数 6 个，合计 1.09 MB。S1 Fig.tif：image/tiff，75.10 KB。S2 Fig.tif：image/tiff，623.27 KB。S3 Fig.tif：image/tiff，222.66 KB。数据集 DOI：10.1371/journal.pone.0152007。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Cell Biology、Genetics、Neuroscience、Pharmacology。主题标签：P 450 enzyme activity、NPC disease patients、NPC 1 patients、drug metabolism defect、NPC 1 disease、bile acid treatment、NPC 1 dysfunction、cytochrome P 450 catalysed dealkylation reactions、vivo drug metabolism studies、P 450 system。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Cell Biology、Genetics、Neuroscience、Pharmacology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Defective_Cytochrome_P450_Catalysed_Drug_Metabolism_in_Niemann_Pick_Type_C_Disease/3131827

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Nicoli, Elena-Raluca; Al Eisa, Nada; V. M. Cluzeau, Celine; Wassif, Christopher A.; Gray, James; R. Burkert, Kathryn; et al. (2016). Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-02，引用时请注意版本时效。