异常LAMP1糖基化可能在尼曼-匹克病C型病理中发挥作用

资源简介

异常LAMP1糖基化可能在尼曼-匹克病C型病理中发挥作用

【数据集背景】

本数据集源站标题为《Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology》。配套论文《Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology》发表于 PLOS ONE（2020），DOI：10.1371/journal.pone.0227829。源站首次发布：2020-01-30。

【数据内容】

源站原始描述：A hallmark of Niemann-Pick disease, type C (NPC) is the progressive degeneration of Purkinje neurons in the cerebellum caused by the accumulation of free cholesterol and glycosphingolipids in the lysosome. Recent studies suggest that the state of glycosylation of lysosomal membrane proteins may play a role in disease progression. Our study has identified the presence of a highly glycosylated form of Lysosome Associated Membrane Protein 1 (LAMP1) that correlated spatiotemporally with Purkinje neu…

【数据结构与技术规格】

文件数 7 个，合计 9.29 MB。pone.0227829.s001.tif：image/tiff，442.35 KB。pone.0227829.s002.tif：image/tiff，289.26 KB。pone.0227829.s003.tif：image/tiff，4.44 MB。数据集 DOI：10.1371/journal.pone.0227829。

【主题与分类】

源站学科分类：Neuroscience、Environmental Sciences not elsewhere classified、Immunology、Biological Sciences not elsewhere classified、Cancer。主题标签：NPC 1 patients、Lysosome Associated Membrane Protein 1、HP βCD treatment、LAMP 1、type C pathology、CSF、Niemann-Pick disease、hyperglycosylated LAMP 1、glycosylated form、Purkinje neuron loss。

【适用方向】

源站学科分类标注为 Neuroscience、Environmental Sciences not elsewhere classified、Immunology、Biological Sciences not elsewhere classified、Cancer。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Abnormal_LAMP1_glycosylation_may_play_a_role_in_Niemann-Pick_disease_type_C_pathology/11773881

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Cawley, Niamh X.; Sojka, Caitlin; Cougnoux, Antony; Lyons, Anna T.; Nicoli, Elena‐Raluca; Wassif, Christopher A.; et al. (2020). Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。