神经元和胶质细胞中Npc1对中枢神经系统髓鞘形成和维持至关重要

资源简介

神经元和胶质细胞中Npc1对中枢神经系统髓鞘形成和维持至关重要

【数据集背景】

本数据集源站标题为《Npc1 Acting in Neurons and Glia Is Essential for the Formation and Maintenance of CNS Myelin》。配套论文《Npc1 Acting in Neurons and Glia Is Essential for the Formation and Maintenance of CNS Myelin》发表于 PLoS Genetics（2013），DOI：10.1371/journal.pgen.1003462。源站首次发布：2013-04-11。

【数据内容】

源站原始描述：Cholesterol availability is rate-limiting for myelination, and prior studies have established the importance of cholesterol synthesis by oligodendrocytes for normal CNS myelination. However, the contribution of cholesterol uptake through the endocytic pathway has not been fully explored. To address this question, we used mice with a conditional null allele of the Npc1 gene, which encodes a transmembrane protein critical for mobilizing cholesterol from the endolysosomal system. Loss of function m…

【数据结构与技术规格】

文件数 4 个，合计 13.48 MB。Figure_S2.tif：image/tiff，2.58 MB。Figure_S3.tif：image/tiff，3.73 MB。数据集 DOI：10.1371/journal.pgen.1003462。

【主题与分类】

源站学科分类：Medicine、Biological Sciences。主题标签：Model organisms、Animal models、mouse、neuroscience、Neurobiology of disease and regeneration、Metabolic disorders、Niemann-Pick disease、acting、neurons、glia。

【适用方向】

源站学科分类标注为 Medicine、Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Npc1_Acting_in_Neurons_and_Glia_Is_Essential_for_the_Formation_and_Maintenance_of_CNS_Myelin_/680060

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Yu, Ting; Lieberman, Andrew P. (2016). Npc1 Acting in Neurons and Glia Is Essential for the Formation and Maintenance of CNS Myelin. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。