GCY-35/GCY-36 鸟苷酸环化酶突变对秀丽隐杆线虫巴德特-别德尔综合征相关表型的修饰作用

资源简介

GCY-35/GCY-36 鸟苷酸环化酶突变对秀丽隐杆线虫巴德特-别德尔综合征相关表型的修饰作用

【数据集背景】

本数据集源站标题为《Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans》。配套论文《Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans》发表于 PLoS Genetics（2011），DOI：10.1371/journal.pgen.1002335。源站首次发布：2011-10-13。

【数据内容】

源站原始描述：Ciliopathies are pleiotropic and genetically heterogeneous disorders caused by defective development and function of the primary cilium. Bardet-Biedl syndrome (BBS) proteins localize to the base of cilia and undergo intraflagellar transport, and the loss of their functions leads to a multisystemic ciliopathy. Here we report the identification of mutations in guanylate cyclases (GCYs) as modifiers of Caenorhabditis elegans bbs endophenotypes. The loss of GCY-35 or GCY-36 results in suppression of…

【数据结构与技术规格】

文件数 7 个，合计 7.01 MB。Figure_S1.tif：image/tiff，768.52 KB。Figure_S2.tif：image/tiff，760.62 KB。Figure_S3.tif：image/tiff，1.56 MB。数据集 DOI：10.1371/journal.pgen.1002335。

【主题与分类】

源站学科分类：Physiology、Molecular Biology、Neuroscience、Genetics、Developmental Biology。主题标签：mutations、guanylate、cyclase、bardet-biedl、phenotypes。

【适用方向】

源站学科分类标注为 Physiology、Molecular Biology、Neuroscience、Genetics、Developmental Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Mutations_in_a_Guanylate_Cyclase_GCY_35_GCY_36_Modify_Bardet_Biedl_Syndrome_Associated_Phenotypes_in_Caenorhabditis_elegans_/132428

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：A. Mok, Calvin; P. Healey, Michael; Shekhar, Tanvi; R. Leroux, Michel; Héon, Elise; Zhen, Mei (2016). Mutations in a Guanylate Cyclase GCY-35/GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。