Ikbkap/Elp1 缺陷通过破坏减数分裂进程导致男性不育

资源简介

Ikbkap/Elp1 缺陷通过破坏减数分裂进程导致男性不育

【数据集背景】

本数据集源站标题为《Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression》。配套论文《Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression》发表于 PLoS Genetics（2013），DOI：10.1371/journal.pgen.1003516。源站首次发布：2013-05-23。

【数据内容】

源站原始描述：Mouse Ikbkap gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized. We used a loss-of-function approach in mice to demonstrate that Ikbkap is essential for meiosis during spermatogenesis. Absence of Ikbkap results in defects in synapsis and meiotic recombination, both of which result in increased apoptosis and complete arrest…

【数据结构与技术规格】

文件数 8 个，合计 7.75 MB。Figure_S1.tif：image/tiff，901.17 KB。Figure_S2.tif：image/tiff，1.12 MB。Figure_S3.tif：image/tiff，2.07 MB。数据集 DOI：10.1371/journal.pgen.1003516。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：genetics、epigenetics、genomics、Chromosome biology、meiosis、deficiency、causes、infertility、disrupting、meiotic。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Ikbkap_Elp1_Deficiency_Causes_Male_Infertility_by_Disrupting_Meiotic_Progression_/706658

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Lin, Fu-Jung; Shen, Li; Jang, Chuan-Wei; Ø. Falnes, Pål; Zhang, Yi (2016). Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。