结节性硬化症患者来源的原代细胞在单倍体不足状态下的自噬改变数据集

资源简介

结节性硬化症患者来源的原代细胞在单倍体不足状态下的自噬改变数据集

【数据集背景】

本数据集源站标题为《Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state》。配套论文《Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state》发表于 Genetics and Molecular Biology（2021），DOI：10.1590/1678-4685-gmb-2020-0475。源站首次发布：2022-05-30。

【数据内容】

源站原始描述：Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozygosity mutations and their treatment involves the use of mTORC1 inhibitors. We aimed to evaluate cellular processes regulated by mTORC1 in TSC cells with different mutations before tumor development. Flow cytometry analyses were performed to evaluate…

【数据结构与技术规格】

文件数 7 个，合计 974.39 KB。数据集 DOI：10.6084/m9.figshare.19923287.v1。

【主题与分类】

源站学科分类：Biochemistry and Cell Biology not elsewhere classified、Genetics not elsewhere classified。主题标签：Autophagy、mTOR inhibitors、neurocutaneous disorder、Rapamycin、Tuberous Sclerosis Complex。

【适用方向】

源站学科分类标注为 Biochemistry and Cell Biology not elsewhere classified、Genetics not elsewhere classified。

【获取与许可】

源站页面：https://scielo.figshare.com/articles/dataset/Primary_cells_derived_from_Tuberous_Sclerosis_Complex_patients_show_autophagy_alteration_in_the_haploinsufficiency_state/19923287

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Rosset, Clévia; Jaeger, Mariane da Cunha; Filippi-Chiela, Eduardo; Reis, Larissa Brussa; Sartor, Ivaine Taís Sauthier; Oliveira Netto, Cristina Brinckmann; et al. (2021). Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state. SciELO…

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。