抑制自噬可减少蛋白质错误折叠引起的视网膜变性

资源简介

抑制自噬可减少蛋白质错误折叠引起的视网膜变性

【数据集背景】

本数据集源站标题为《Inhibiting autophagy reduces retinal degeneration caused by protein misfolding》。配套论文《Inhibiting autophagy reduces retinal degeneration caused by protein misfolding》发表于 Autophagy（2018），DOI：10.1080/15548627.2018.1463121。项目资助方：This study was supported (in part) by a Sybil B. Harrington Physician Scientist Award from Research to Prevent Blindness, New York, NY (DNZ). Additional support was provided by National Eye Institute R01-EY-020823 (DNZ), Foundation Fighting Blindness (DNZ), University of Michigan Core Center for Vision Research (NEI-EY007003), Washington University Department of Ophthalmology and Visual Sciences Core Grant (EY02687), and NIH grant GM053396 (DJK); HHS | NIH | National Eye Institute (NEI) [EY-007003]; HHS | NIH | National Eye Institute (NEI) [EY-020823]; Research Prevent Blindness, Inc [DNZ]; Foundation Fighting Blindness (FFB) [DNZ]; HHS | NIH | National Eye Institute (NEI)[EY-02687].。源站首次发布：2019-10-24。

【数据内容】

源站原始描述：Mutations in the genes necessary for the structure and function of vertebrate photoreceptor cells are associated with multiple forms of inherited retinal degeneration. Mutations in the gene encoding RHO (rhodopsin) are a common cause of autosomal dominant retinitis pigmentosa (adRP), with the Pro23His variant of RHO resulting in a misfolded protein that activates endoplasmic reticulum stress and the unfolded protein response. Stimulating macroautophagy/autophagy has been proposed as a strategy f…

【数据结构与技术规格】

文件数 2 个，合计 799.78 KB。2017AUTO0628R1-s02.tif：image/tiff，785.26 KB。Figure S1.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，14.51 KB。数据集 DOI：10.6084/m9.figshare.6815780.v2。

【主题与分类】

源站学科分类：Biophysics、Biochemistry、Medicine、Cell Biology、Genetics、Neuroscience。主题标签：Autophagy、proteasome、protein misfolding、retinal degeneration、Rhodopsin。

【适用方向】

源站学科分类标注为 Biophysics、Biochemistry、Medicine、Cell Biology、Genetics、Neuroscience。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/Inhibiting_autophagy_reduces_retinal_degeneration_caused_by_protein_misfolding/6815780

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Inhibiting autophagy reduces retinal degeneration caused by protein misfolding. Taylor & Francis. Yao, Jingyu; Qiu, Yaoyan; Frontera, Eric; Jia, Lin; Khan, Naheed W.; Klionsky, Daniel J.; et al

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。