SLC26A9基因与囊性纤维化患者Ivacaftor肺功能反应关联数据（DOC表格）

数据集获取（Figshare）

• 源站标题：Table_1_SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis.DOC
• DOI：10.3389/fphar.2018.00828.s001
• 发布日期：2018-07-26
• 文件数：1 个
• 文件总体积：51.71 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_SLC26A9_Gene_Is_Associated_With_Lung_Function_Response_to_Ivacaftor_in_Patients_With_Cystic_Fibrosis_DOC/6864743

命令行下载

curl -L -o "Table_1_SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis.DOC" "https://ndownloader.figshare.com/files/12524051"

文件清单

• Table_1_SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis.DOC（51.71 KB）

文件总体积 51.71 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Ivacaftor is a drug used to treat cystic fibrosis (CF) patients carrying specific gating CFTR mutations. Interpatient variability in the lung response has been shown to be partly explained by rs7512462 in the Solute Carrier Family 26 Member 9 (SLC26A9) gene. In an independent and larger cohort, we aimed to evaluate whether SLC26A9 variants contribute to the variability of the lung phenotype and if they influence the lung response to ivacaftor. We genotyped the French CF Gene Modifier Study cohort (n = 4,840) to investigate whether SLC26A9 variants were involved in the lung phenotype heterogeneity. Their influence in the response to ivacaftor was tested in the 30 treated patients who met the inclusion criteria: older than 6 years of age, percent-predicted forced expiratory volume measured in 1 s (FEV1pp) in the 3 months before treatment initiation ranging between 40 and 90%. Response to treatment was determined by the change in FEV1pp from baseline, averaged in 15–75 days, and the 1st-year post-treatment. We observed that SLC26A9 variants were not associated with lung function variability in untreated patients and that gain of lung function in patients treated with ivacaftor was similar to clinical trials. We confirmed that rs7512462 was associated with variability in ivacaftor-lung response, with a significant reduction in lung function improvement for patients with the C allele. Other SLC26A9 SNPs also contributed to the ivacaftor-response. Interindividual variability in lung response to ivacaftor is associated with SLC26A9 variants in French CF patients. Pharmacogenomics and personalized medicine will soon be part of CF patient care.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fphar.2018.00828.s001（source: https://frontiersin.figshare.com/articles/dataset/Table_1_SLC26A9_Gene_Is_Associated_With_Lung_Function_Response_to_Ivacaftor_in_Patients_With_Cystic_Fibrosis_DOC/6864743）。