泊马度胺在鼠模型中显著抗中枢神经系统淋巴瘤并影响肿瘤微环境

资源简介

泊马度胺在鼠模型中显著抗中枢神经系统淋巴瘤并影响肿瘤微环境

【数据集背景】

本数据集源站标题为《Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models》。配套论文《Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models》发表于 PLoS ONE（2013），DOI：10.1371/journal.pone.0071754。源站首次发布：2013-08-05。

【数据内容】

源站原始描述：Primary CNS lymphoma carries a poor prognosis. Novel therapeutic agents are urgently needed. Pomalidomide (POM) is a novel immunomodulatory drug with anti-lymphoma activity. CNS pharmacokinetic analysis was performed in rats to assess the CNS penetration of POM. Preclinical evaluation of POM was performed in two murine models to assess its therapeutic activity against CNS lymphoma. The impact of POM on the CNS lymphoma immune microenvironment was evaluated by immunohistochemistry and immunofluor…

【数据结构与技术规格】

文件数 6 个，合计 14.43 MB。File_S1.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，15.76 KB。Figure_S1.tif：image/tiff，1.23 MB。Figure_S2.tif：image/tiff，3.10 MB。数据集 DOI：10.1371/journal.pone.0071754。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：shows、therapeutic、cns、lymphoma、microenvironment、murine。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Pomalidomide_Shows_Significant_Therapeutic_Activity_against_CNS_Lymphoma_with_a_Major_Impact_on_the_Tumor_Microenvironment_in_Murine_Models_/765192

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Li, Zhimin; Qiu, Yushi; Personett, David; Huang, Peng; Edenfield, Brandy; Katz, Jason; et al. (2016). Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-09，引用时请注意版本时效。