Gpnmb 是尼曼-匹克病C型内脏病理学的潜在标志物

资源简介

Gpnmb 是尼曼-匹克病C型内脏病理学的潜在标志物

【数据集背景】

本数据集源站标题为《Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease》。配套论文《Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0147208。源站首次发布：2016-01-28。

【数据内容】

源站原始描述：Impaired function of NPC1 or NPC2 lysosomal proteins leads to the intracellular accumulation of unesterified cholesterol, the primary defect underlying Niemann-Pick type C (NPC) disease. In addition, glycosphingolipids (GSLs) accumulate in lysosomes as well. Intralysosomal lipid accumulation triggers the activation of a set of genes, including potential biomarkers. Transcript levels of Gpnmb have been shown to be elevated in various tissues of an NPC mouse model. We speculated that Gpnmb could s…

【数据结构与技术规格】

文件数 3 个，合计 2.57 MB。S1_Fig.tif：image/tiff，2.49 MB。S1_Table.xls：application/vnd.ms-excel，49.15 KB。S1_Text.doc：application/msword，31.23 KB。数据集 DOI：10.1371/journal.pone.0147208。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：unesterified cholesterol、transcript levels、glucosylceramide synthase、intracellular accumulation、protein level、Potential Marker、gcs、Visceral Pathology、NPC mice、Gpnmb expression。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Gpnmb_Is_a_Potential_Marker_for_the_Visceral_Pathology_in_Niemann_Pick_Type_C_Disease_/1638237

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：R. A. Marques, André; L. Gabriel, Tanit; Aten, Jan; P. A. A. van Roomen, Cindy; Ottenhoff, Roelof; Claessen, Nike; et al. (2016). Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。