UCI_Clu-h2kbKI 研究数据集
Clu-h2kbKI 等位基因通过育种引入 5xFAD 半合子。Clu-h2kbKI 纯合子、5xFAD 半合子、Clu-h2kbKI 半合子；5xFAD 半合子和 WT（C57BL6J）队列由 UCI 转基因小鼠设施通过体外受精或育种产生，并维持在 14/10 小时光/暗周期
基本信息
资源简介
UCI_Clu-h2kbKI 研究数据集
Clu-h2kbKI 等位基因通过育种引入 5xFAD 半合子。Clu-h2kbKI 纯合子、5xFAD 半合子、Clu-h2kbKI 半合子；5xFAD 半合子和 WT（C57BL6J）队列由 UCI 转基因小鼠设施通过体外受精或育种产生，并维持在 14/10 小时光/暗周期
【数据内容】
源站描述（机器翻译，仅供参考）：UCI_Clu-rs2279590_h2kb 研究数据集 研究缩写：UCI_Clu-h2kbKI 研究描述：本研究提供以下小鼠的 bulk RNA-seq、免疫组化和生物化学数据：1. C57BL/6J（Jax 库存编号：000664）2. 5xFAD 半合子（Jax 库存编号：034848）3. Clu-h2kbKI（C57BL/6J-Clu /J 纯合子；Jax 库存编号：037496）4. 5xFAD;Clu-h2kbKI Clu-h2kbKI（C57BL/6J-Clu /J 纯合子）等位基因模拟人类 rs2279590 变异。为澄清起见，Clu-rs2279590 或 C57BL/6J-Clu /J 在本研究中称为 Clu-h2kbKI。Clu-h2kbKI 等位基因通过育种引入 5xFAD 半合子。Clu-h2kbKI 纯合子、5xFAD 半合子、Clu-h2kbKI 半合子；5xFAD 半合子和 WT（C57BL6J）队列由 UCI 转基因小鼠设施通过体外受精或育种产生，并维持在 14/10 小时光/暗周期。为尽量减少 g
【主题与分类】
主题标签：阿尔茨海默病、神经系统疾病、bulk RNA-seq、免疫组化、生物化学、小鼠模型、rs2279590。本站分类：神经系统疾病/阿尔茨海默病。
【获取与许可】
源站页面：https://synapse.org/Synapse:syn68724130
下载信息
注册下载
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使用方式
数据集获取
源站：https://synapse.org/Synapse:syn68724130
标准获取流程：
- 访问源站链接，注册/登录账号；
- 进入数据集详情页，按页面指引申请权限或直接下载；
- 部分平台提供 SDK，例如：
- OpenDataLab:
pip install openxlab后openxlab.dataset.get(...) - ModelScope:
pip install modelscope后modelscope download - 天池: 登录后页面提供直链下载
以源站「数据下载/使用文档」页面为准。
- OpenDataLab:
数据说明
The UCI_Clu-rs2279590_h2kb Study Dataset Study abbreviation: UCI_Clu-h2kbKI ####** Study Description**: This study provides bulk RNA-seq, immunohistochemistry and biochemistry data of the following mice: 1. C57BL/6J (Jax stock number: 000664) 2. 5xFAD hemizygous (Jax stock number: 034848) 3. Clu-h2kbKI (C57BL/6J-Clu /J homozygous; Jax stock number: 037496) 4. 5xFAD;Clu-h2kbKI Clu-h2kbKI (C57BL/6J-Clu /J homozygous) allele models the human rs2279590 variant. For clarification, Clu-rs2279590 or C57BL/6J-Clu /J is presented as Clu-h2kbKI under this study. Clu-h2kbKI allele was introduced on to 5xFAD hemizygous by breeding. Cohorts of Clu-h2kbKI homozygous, 5xFAD hemizygous, Clu-h2kbKI hemizygous; 5xFAD hemizygous and WT (C57BL6J) were generated by in vitro fertilization or breeding in the Transgenic Mouse Facility at UCI and maintained in a 14/10-hour light/dark cycle. To minimize gene expression variation between mice, all mice in experimental cohorts were bred in the same mouse room and were aged together (to the extent possible). Female and male littermate mice aged 4 and 12 months old were used in this study. All experiments involving mice were approved by the UC Irvine Institutional Animal Care and Use Committee and were conducted in compliance with all relevant ethical regulations for animal testing and research. ####** Methods Description**: Mice were bred in the Transgenic Mouse Facility at UCI and maintained under a 14/10-hour light/dark cycle. To reduce variability in gene expression across animals, all mice in the experimental cohorts were bred in the same room and aged together to the extent possible. Littermate mice aged 4 and 12 months were used for this study. At 4 months, hippocampi were dissected, fresh frozen, and pulverized. Half of the tissue was reserved for bulk RNA sequencing. At 12 months, both hippocampi and cortices were dissected, fresh frozen, and pulverized, with half of the hippocampal tissue and one-third of cortical tissue preser
数据加载示例（图像类）
from PIL import Image
import glob, os
files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)
# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path) # 要求 子目录=类别
目录组织与标注格式以源站说明和下载后实际文件为准。
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