FreshMicro 人类小胶质细胞调控组研究

数据集获取

源站：https://synapse.org/Synapse:syn25671134

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

The Fresh Microglia Regulome (FreshMicro) Study Genetics of the human microglia regulome refines Alzheimer’s disease risk loci **Sample information **: All brain specimens were obtained through informed consent and/or brain donation programs at the respective organizations. All procedures and research protocols were approved by the corresponding ethical committees of our collaborator’s institutions. Autopsies: The autopsy brain specimens originated from brain donation programs at Rush University Medical Center/Rush Alzheimer’s Disease Center (RADC) in Chicago, IL and The Mount Sinai/JJ Peters VA Medical Center NIH Brain and Tissue Repository (NBTR) in the Bronx, NY. RADC: Samples were collected at RADC in Chicago, IL as part of two prospective studies of aging: the Religious Orders Study (ROS) (1) and the Memory and Aging Project (MAP) (2). At the time of enrollment, participants had to be at least 53 (ROS) or 55 (MAP) years old and non-demented at the time of enrollment, and were required to sign an Anatomical Gift Act agreeing to donate their brain and spinal cord at the time of death. Extensive annual neuropsychologic evaluations were collected prior to death, with a structured, quantitative neuropathologic examination conducted at autopsy, described at https://www.radc.rush.edu/docs/var/variables.htm. After autopsy, the collected tissue was weighted, placed in ice-cold MACS tissue storage solution (Miltenyi Biotec, cat# 130-100-008) and shipped overnight at 4°C with priority shipping. Show More NBTR: Samples were collected at NBTR following similar parameters to MSBB–Mount Sinai NIH Neurobiobank cohort (3). Collected autopsies were selected to represent a full spectrum of cognitive and neuropathological disease severity in the absence of discernable non-AD neuropathology. All neuropsychological, diagnostic and autopsy protocols were approved by the Mount Sinai and JJ Peters VA Medical Center Institutional Review Boards, with neuropathological

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。