DukeAD_PTSD：阿尔茨海默病与PTSD共享遗传研究数据

数据集获取

源站：https://synapse.org/Synapse:syn23585917

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

###Duke Study of Shared Genetic, Epigenetic, and Transcriptomic Profiles Between AD and PTSD (DukeAD_PTSD) This study presents the results and data of a study of shared genetic etiology that underlies late-onset Alzheimer’s disease and post traumatic stress syndrome as reported in the manuscript “Shared Genetic Etiology Underlying Late-Onset Alzheimer’s Disease and Post Traumatic Stress Syndrome” by Lutz et al.^1^ A discovery and replication analysis was conducted for cohorts with primarily European Ancestry. The discovery analysis utilized GWAS summary statistics from the International Genomics of Alzheimer’s Disease (IGAP) project for Alzheimer’s disease statistics and the Psychiatric Genomics Consortium (PGC) statistics for PTSD. Replication was performed using the IGAP summary statistics and an independent PTSD dataset from the STRONG STAR consortium for PTSD. To extend the work to individuals with non-European genetic ancestries, a parallel analysis was conducted using data from GWAS studies for Alzheimer’s disease and PTSD in African Americans. Data provided in the project include all of the conditional false discovery rate statistics used in the analysis of genetic pleiotropy reported in Lutz et al.^1^ : Late-onset Alzheimer’s disease conditional with PTSD Q(LOAD|PTSD) and PTSD conditional with LOAD Q(PTSD|LOAD). These statistics can be used for follow up analysis including construction of polygenic risk scores. Show More References to all of the data sets, samples sizes and number of SNPs are summarized in this table: {| class=“border text-align-center” ->Disease/Trait n SNPs, n Reference<- — | — | — | — LOAD, IGAP stage 1 | 63,976 (21,982 LOAD cases, 41,994 controls) | 11,480,632 | Kunkle^1^ PTSD, PGC (European American) | 9,537 (2424 PTSD cases, 7,113 controls) | 13,207,411 | Duncan^2^ PTSD, STRONG STAR | 2,056 (1,011 PTSD cases, 1,045 controls) | 5,086,096 | Nievergelt^

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。