非经典表型甲状腺乳头状癌分子与临床特征数据集

数据集获取（Figshare）

• 源站标题：Table_2_Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype.xlsx
• DOI：10.3389/fendo.2023.1138100.s006
• 发布日期：2023-04-12
• 文件数：1 个
• 文件总体积：13.99 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_2_Molecular_and_clinical_features_of_papillary_thyroid_cancer_in_adult_patients_with_a_non-classical_phenotype_xlsx/22590517

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curl -L -o "Table_2_Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype.xlsx" "https://ndownloader.figshare.com/files/40105774"

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• Table_2_Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype.xlsx（13.99 KB）

文件总体积 13.99 KB（源站 API 实测）。

数据说明

PurposeGenotyping is fundamental in papillary thyroid cancer (PTC) and helps to enhance diagnosis and prognosis and determine appropriate treatments. The phenotype-genotype association in PTC was previously studied, with BRAF V600E characterizing classic PTC and tall-cell PTC and RAS mutations characterizing follicular-variant PTC. In clinic, some non-classical histological subtypes of PTC were also identified, however, their genotype remains unclear. In this study, we collected samples of these non-classical PTC after the exclusion of classic phenotypes and examined their phenotypes, genotype and the relationship between phenotype and genotype.
MethodsWe screened out non-classical PTC by excluding classical PTC from 1,059 different thyroid samples, and a total of 24 cases was obtained and described from the morphological features, which is rare in differentiated PTC. DNA/RNA sequencing was performed using 18 available samples to describe the genetic features.
ResultsPTC with the non-classical phenotype were characterized cuboidal to low columnar tumor cells with subtle nuclear features of PTC and without discernible nuclear elongation, concurrently with dense microfollicles, delicate papillae or solid nodules with delicate fibrovascular cores. They were associated with lymphatic vessel invasion (POur study retrospectively screened a large cohort of different thyroid tissue samples, and presented the histopathological and genetic features of a non-classical phenotype of PTC from 24 patients. It may contribute to diagnose in PTC, and patients of these non-classical phenotype may benefit from targeted therapy, compared to a natural patient cohort without selection.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fendo.2023.1138100.s006（source: https://frontiersin.figshare.com/articles/dataset/Table_2_Molecular_and_clinical_features_of_papillary_thyroid_cancer_in_adult_patients_with_a_non-classical_phenotype_xlsx/22590517）。