父系早期遗传性卵巢癌：家族性卵巢癌登记研究

资源简介

父系早期遗传性卵巢癌：家族性卵巢癌登记研究

【数据集背景】

本数据集源站标题为《Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study》。配套论文《Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study》发表于 PLOS Genetics（2018），DOI：10.1371/journal.pgen.1007194。源站首次发布：2018-02-15。

【数据内容】

源站原始描述：Given prior evidence that an affected woman conveys a higher risk of ovarian cancer to her sister than to her mother, we hypothesized that there exists an X-linked variant evidenced by transmission to a woman from her paternal grandmother via her father. We ascertained 3,499 grandmother/granddaughter pairs from the Familial Ovarian Cancer Registry at the Roswell Park Cancer Institute observing 892 informative pairs with 157 affected granddaughters. We performed germline X-chromosome exome sequen…

【数据结构与技术规格】

文件数 4 个，合计 5.14 MB。S1 Fig.tif：image/tiff，1.34 MB。S2 Fig.tif：image/tiff，1.21 MB。S3 Fig.tif：image/tiff，901.41 KB。数据集 DOI：10.1371/journal.pgen.1007194。

【主题与分类】

源站学科分类：Genetics、Biotechnology、Biological Sciences not elsewhere classified、Science Policy。主题标签：carrier families、missense variant、exome sequencing、risk stratification、germline X-chromosome exome sequencing、Familial Ovarian Cancer Registry、BRCA、X-linked pattern、hazard ratio HR、MAGEC 3。

【适用方向】

源站学科分类标注为 Genetics、Biotechnology、Biological Sciences not elsewhere classified、Science Policy。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Paternal_lineage_early_onset_hereditary_ovarian_cancers_A_Familial_Ovarian_Cancer_Registry_study/5892166

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：H. Eng, Kevin; Szender, J. Brian; Etter, John Lewis; Kaur, Jasmine; Poblete, Samantha; Huang, Ruea-Yea; et al. (2018). Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。