高风险神经母细胞瘤中基因融合用于药物重定位的表1

数据集获取（Figshare）

• 源站标题：table1_Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma.xlsx
• DOI：10.3389/fphar.2021.608778.s005
• 发布日期：2021-04-23
• 文件数：1 个
• 文件总体积：239.68 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/table1_Unraveling_Gene_Fusions_for_Drug_Repositioning_in_High-Risk_Neuroblastoma_xlsx/14473212

命令行下载

curl -L -o "table1_Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma.xlsx" "https://ndownloader.figshare.com/files/27699468"

文件清单

• table1_Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma.xlsx（239.68 KB）

文件总体积 239.68 KB（源站 API 实测）。

数据说明

High-risk neuroblastoma (NB) remains a significant therapeutic challenge facing current pediatric oncology patients. Structural variants such as gene fusions have shown an initial promise in enhancing mechanistic understanding of NB and improving survival rates. In this study, we performed a comprehensive in silico investigation on the translational ability of gene fusions for patient stratification and treatment development for high-risk NB patients. Specifically, three state-of-the-art gene fusion detection algorithms, including ChimeraScan, SOAPfuse, and TopHat-Fusion, were employed to identify the fusion transcripts in a RNA-seq data set of 498 neuroblastoma patients. Then, the 176 high-risk patients were further stratified into four different subgroups based on gene fusion profiles. Furthermore, Kaplan-Meier survival analysis was performed, and differentially expressed genes (DEGs) for the redefined high-risk group were extracted and functionally analyzed. Finally, repositioning candidates were enriched in each patient subgroup with drug transcriptomic profiles from the LINCS L1000 Connectivity Map. We found the number of identified gene fusions was increased from clinical the low-risk stage to the high-risk stage. Although the technical concordance of fusion detection algorithms was suboptimal, they have a similar biological relevance concerning perturbed pathways and regulated DEGs. The gene fusion profiles could be utilized to redefine high-risk patient subgroups with significant onset age of NB, which yielded the improved survival curves (Log-rank p value ≤ 0.05). Out of 48 enriched repositioning candidates, 45 (93.8%) have antitumor potency, and 24 (50%) were confirmed with either on-going clinical trials or literature reports. The gene fusion profiles have a discrimination power for redefining patient subgroups in high-risk NB and facilitate precision medicine-based drug repositioning implementation.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fphar.2021.608778.s005（source: https://frontiersin.figshare.com/articles/dataset/table1_Unraveling_Gene_Fusions_for_Drug_Repositioning_in_High-Risk_Neuroblastoma_xlsx/14473212）。