回顾性队列中血清MicroRNA水平与高级别前列腺癌缺失的关联数据集

数据集获取（Figshare）

• 源站标题：Elevated Serum MicroRNA Levels Associate with Absence of High-Grade Prostate Cancer in a Retrospective Cohort
• DOI：10.1371/journal.pone.0124245
• 发布日期：2015-04-14
• 文件数：5 个
• 文件总体积：3.81 MB
• 源站页面：https://plos.figshare.com/articles/dataset/_Elevated_Serum_MicroRNA_Levels_Associate_with_Absence_of_High_Grade_Prostate_Cancer_in_a_Retrospective_Cohort_/1379079

命令行下载

curl -L -o "S1_Dataset.xlsx" "https://ndownloader.figshare.com/files/2020006"
curl -L -o "S1_Fig.tif" "https://ndownloader.figshare.com/files/2020007"
curl -L -o "S2_Fig.tif" "https://ndownloader.figshare.com/files/2020008"
curl -L -o "S3_Fig.tif" "https://ndownloader.figshare.com/files/2020009"
curl -L -o "S4_Fig.tif" "https://ndownloader.figshare.com/files/2020010"

文件清单

• S1_Dataset.xlsx（54.78 KB）
• S1_Fig.tif（884.71 KB）
• S2_Fig.tif（881.77 KB）
• S3_Fig.tif（902.23 KB）
• S4_Fig.tif（1.08 MB）

文件总体积 3.81 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

To reduce treatment of indolent prostate cancer (PCa), biomarkers are needed to improve identification of patients with a low-risk of having aggressive disease. Over-treatment of these patients occurs because of uncertainty in the aggressiveness of the entire tumor based on the biopsies, which do not accurately sample multifocal tumors. Circulating microRNAs (miRNAs) are stable serum markers and differential miRNA levels occur in men with PCa. The goal of this study was to identify circulating miRNAs that were associated with aggressive or indolent PCa. We measured circulating miRNAs in 150 patients prior to surgery and compared the miRNA levels to the pathology of the entire radical prostatectomy specimen. For this study we used an exceptionally well-characterized cohort of patients who had benign prostatic hyperplasia (BPH), low-grade or high-grade PCa. Low-grade was defined as patients with 100% Gleason grade 3 tumor as determined by step-wise sectioning. High-grade PCa patients had 30-90% Gleason grade 4+5 in the tumor. BPH patients had at least two biopsies negative for PCa. Twenty one miRNAs were selected for analysis. The miRNAs were quantified by RT-qPCR and analyzed by logistic regression. High levels of 14 miRNAs were exclusively present in the serum from patients with low-grade PCa or BPH, compared to men with high-grade PCa who had consistently low levels. The expression levels of the 14 miRNAs were combined into a “miR Score” which had a negative predictive value (NPV) of 0.939 to predict absence of high-grade PCa among PCa and BPH patients. Biochemical recurrence (BCR) was known for the PCa patients and a combined “miR Risk Score” accurately classified a subset of patients with low risk of BCR (NPV 0.941). In summary, measurement of serum miRNAs may have pre-surgical utility in combination with clinical risk calculators to identify patients with low risk of harboring aggressive PCa.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0124245（source: https://plos.figshare.com/articles/dataset/_Elevated_Serum_MicroRNA_Levels_Associate_with_Absence_of_High_Grade_Prostate_Cancer_in_a_Retrospective_Cohort_/1379079）。