伊布替尼抑制BTK和ITK在小鼠慢性移植物抗宿主病预防中的作用研究数据集

资源简介

伊布替尼抑制BTK和ITK在小鼠慢性移植物抗宿主病预防中的作用研究数据集

【数据集背景】

本数据集源站标题为《Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice》。配套论文《Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0137641。源站首次发布：2015-09-08。

【数据内容】

源站原始描述：Bruton’s Tyrosine Kinase (BTK) and IL-2 Inducible T-cell Kinase (ITK) are enzymes responsible for the phosphorylation and activation of downstream effectors in the B-cell receptor (BCR) signaling and T cell receptor (TCR) signaling pathways, respectively. Ibrutinib is an FDA-approved potent inhibitor of both BTK and ITK that impairs B-cell and T-cell function. CD4 T cells and B cells are essential for the induction of chronic graft-versus-host disease (cGVHD). We evaluated these targets by testi…

【数据结构与技术规格】

文件数 5 个，合计 3.36 MB。S1_Fig.tif：image/tiff，329.68 KB。S2_Fig.tif：image/tiff，348.54 KB。S3_Fig.tif：image/tiff，423.02 KB。数据集 DOI：10.1371/journal.pone.0137641。

【主题与分类】

源站学科分类：Uncategorised。主题标签：CD 4 T cells、itk、Mouse models、tcr、bcr、T cell receptor、btk、b cells、cgvhd、costimulatory molecule activation。

【适用方向】

源站学科分类标注为 Uncategorised。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Inhibition_of_BTK_and_ITK_with_Ibrutinib_Is_Effective_in_the_Prevention_of_Chronic_Graft_versus_Host_Disease_in_Mice_/1537301

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：D. Schutt, Steven; Fu, Jianing; Nguyen, Hung; Bastian, David; Heinrichs, Jessica; Wu, Yongxia; et al. (2016). Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-02，引用时请注意版本时效。