选择性CD73阻断增强小鼠移植物抗宿主病数据集

资源简介

选择性CD73阻断增强小鼠移植物抗宿主病数据集

【数据集背景】

本数据集源站标题为《Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice》。配套论文《Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice》发表于 PLoS ONE（2013），DOI：10.1371/journal.pone.0058397。源站首次发布：2013-03-09。

【数据内容】

源站原始描述：CD73 functions as an ecto-5′-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models. Survival of wild-type (WT) recipients of either allogeneic donor naïve CD73 knock-out (KO) or WT T cells was similar suggesting that donor naïve T cell CD73 did not contribute to GVHD. By contrast, donor CD73 KO CD4+CD25+ regulatory T cells (Treg) had significantly impa…

【数据结构与技术规格】

文件数 4 个，合计 451.30 KB。Figure_S1.pdf：application/pdf，180.72 KB。Figure_S2.pdf：application/pdf，126.36 KB。Figure_S3.pdf：application/pdf，103.76 KB。数据集 DOI：10.1371/journal.pone.0058397。

【主题与分类】

源站学科分类：Mathematics、Cell Biology、Hematology、Immunology。主题标签：graft-versus-host、enhanced、selective、cd73、blockade、mice。

【适用方向】

源站学科分类标注为 Mathematics、Cell Biology、Hematology、Immunology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Graft_versus_Host_Disease_Is_Enhanced_by_Selective_CD73_Blockade_in_Mice__/649080

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Wang, Long; Fan, Jie; Chen, Siqi; Zhang, Yi; J. Curiel, Tyler; Zhang, Bin (2016). Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。