体内消耗表达淋巴毒素-α的淋巴细胞可抑制异种移植物抗宿主病

资源简介

体内消耗表达淋巴毒素-α的淋巴细胞可抑制异种移植物抗宿主病

【数据集背景】

本数据集源站标题为《In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease》。配套论文《In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0033106。源站首次发布：2012-03-12。

【数据内容】

源站原始描述：Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic cell transplantation and is largely mediated by activated donor lymphocytes. Lymphotoxin (LT)-α is expressed by subsets of activated T and B cells, and studies in preclinical models demonstrated that targeted depletion of these cells with a mouse anti-LT-α monoclonal antibody (mAb) was efficacious in inhibiting inflammation and autoimmune disease. Here we demonstrate that LT-α is also upregulated on activa…

【数据结构与技术规格】

文件数 2 个，合计 290.10 KB。Figure_S1.tif：image/tiff，181.09 KB。Figure_S2.tif：image/tiff，109.01 KB。数据集 DOI：10.1371/journal.pone.0033106。

【主题与分类】

源站学科分类：Immunology。主题标签：depletion、lymphotoxin-alpha、expressing、lymphocytes、inhibits、xenogeneic、graft-versus-host-disease。

【适用方向】

源站学科分类标注为 Immunology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_In_Vivo_Depletion_of_Lymphotoxin_Alpha_Expressing_Lymphocytes_Inhibits_Xenogeneic_Graft_versus_Host_Disease/127817

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Y. Chiang, Eugene; Kolumam, Ganesh; M. McCutcheon, Krista; Young, Judy; Lin, Zhonghua; Balazs, Mercedesz; et al. (2016). In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。