表4_DDR1作为非小细胞肺癌关键预后生物标志物：识别、验证与潜在治疗意义

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• 源站标题：Table 4_DDR1 as a key prognostic biomarker in non-small cell lung cancer: identification, validation, and potential therapeutic implications.xlsx
• DOI：10.3389/fimmu.2025.1690829.s004
• 发布日期：2025-11-28
• 文件数：1 个
• 文件总体积：24.74 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_4_DDR1_as_a_key_prognostic_biomarker_in_non-small_cell_lung_cancer_identification_validation_and_potential_therapeutic_implications_xlsx/30737441

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• Table 4_DDR1 as a key prognostic biomarker in non-small cell lung cancer: identification, validation, and potential therapeutic implications.xlsx（24.74 KB）

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数据说明

BackgroundNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death, with a limited response to immune checkpoint inhibitors (ICIs). Discoidin domain receptor 1 (DDR1) is a collagen-binding kinase that is implicated in tumor progression and immune escape, but its role in NSCLC is unclear. This study aimed to clarify the clinical significance and therapeutic potential of DDR1 via bioinformatics, machine learning, in vitro experiments, and clinical sample analysis.
Materials and MethodsNSCLC patients were stratified by DDR1 expression based on retrospective RNA-seq data from The Cancer Genome Atlas (TCGA); after quality control, 495 lung adenocarcinoma (LUAD) and 481 lung squamous cell carcinoma (LUSC) tumor samples, together with 57 LUAD and 48 LUSC normal samples, were retained for further analysis. The analyses included survival, mutation, immune landscape, drug sensitivity, single-cell heterogeneity, and functional Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, accounting for the heterogeneity among NSCLC subtypes. A machine learning-based 4-gene prognostic model was constructed and externally validated using two independent datasets: GSE30219 (GPL570 platform, 278 NSCLC samples) and GSE41271 (GPL6884 platform, 274 NSCLC samples). The biological functions of DDR1 were further evaluated via in vitro assays and immunohistochemistry (IHC) of clinical samples.
ResultsHigh DDR1 expression was correlated with advanced T stage (POur study demonstrated that DDR1 promotes tumor progression and immune evasion and is frequently overexpressed in NSCLC patients, suggesting that DDR1 is a potential prognostic biomarker and therapeutic target.

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CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fimmu.2025.1690829.s004（source: https://frontiersin.figshare.com/articles/dataset/Table_4_DDR1_as_a_key_prognostic_biomarker_in_non-small_cell_lung_cancer_identification_validation_and_potential_therapeutic_implications_xlsx/30737441）。