伊马替尼甲磺酸盐治疗HES、PV、非典型慢性粒细胞白血病(CML)或慢性粒单核细胞白血病(CMML)及肥大细胞增多症

该数据集来自clinicaltrials.gov,聚焦伊马替尼甲磺酸盐用于治疗慢性粒单核细胞白血病、慢性粒细胞白血病、真性红细胞增多症、嗜酸性粒细胞增多综合征及肥大细胞增多症的临床研究

M.D. Anderson Cancer CenterM.D. Anderson Cancer Center
clinicaltrials
浏览 8
蛋白质分类Chronic Myelomonocytic LeukemiaChronic Myeloid LeukemiaPolycythemia VeraHypereosinophilic SyndromeMastocytosis
Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate

基本信息

模态
蛋白质
任务类型
分类
创建/更新时间
2026-10-12

资源简介

伊马替尼甲磺酸盐治疗HES、PV、非典型慢性粒细胞白血病(CML)或慢性粒单核细胞白血病(CMML)及肥大细胞增多症

该数据集来自clinicaltrials.gov,聚焦伊马替尼甲磺酸盐用于治疗慢性粒单核细胞白血病、慢性粒细胞白血病、真性红细胞增多症、嗜酸性粒细胞增多综合征及肥大细胞增多症的临床研究。数据覆盖上述血液系统疾病的患者用药方案,包括每日口服剂量、HES患者的起始剂量与剂量调整、服药方式及每月供药与回收流程,并允许继续使用口服羟基脲控制血细胞计数。可用于血液肿瘤治疗响应、用药依从性及剂量调整相关研究(来源 clinicaltrials.gov)。

【数据内容】

源站描述(机器翻译,仅供参考):条件:慢性粒单核细胞白血病、慢性粒细胞白血病、真性红细胞增多症、嗜酸性粒细胞增多综合征、肥大细胞增多症。伊马替尼甲磺酸盐是一种化合物,可阻断导致某种白血病的蛋白质。然而,伊马替尼甲磺酸盐还阻断其他可能导致其他血液疾病(如骨髓增殖性疾病)的重要蛋白质。本研究中的患者将每天口服4片伊马替尼甲磺酸盐。HES患者将开始每天服用1片,根据反应可能增至每天4片。伊马替尼甲磺酸盐应每天早晨早餐时用一大杯水服用。装有药片的瓶子将每月发给患者。未使用的药物必须在研究结束时归还。正在口服羟基脲以控制血细胞计数的患者,可在研究期间继续服用

【主题与分类】

主题标签:Chronic Myelomonocytic Leukemia、Chronic Myeloid Leukemia、Polycythemia Vera、Hypereosinophilic Syndrome、Mastocytosis。本站分类:肿瘤/白血病。

【获取与许可】

源站页面:https://clinicaltrials.gov/study/NCT00038675

官方服务

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从合规授权、采集治理、专业标注到数据集交付,我们提供全链路闭环服务,让高质量临床数据即拿即用。

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下载信息

注册下载

需要注册 Kaggle 账号并登录后下载,适合需要跟踪下载记录和使用 API 的用户。

暂未开放

公开下载

无需注册即可直接获取公开样本或文档,适合快速预览和评估数据集质量。

免登录

有偿下载

公开数据集受托下载与技术交付服务。

提供高速下载与技术交付服务(收技术服务费,非数据销售)

暂未开放

当前数据集主要来源为 Kaggle 公开托管,完整影像包建议通过原始链接或 Kaggle API 获取。

使用方式

数据集获取

源站:https://clinicaltrials.gov/study/NCT00038675

标准获取流程:

  1. 访问源站链接,注册/登录账号;
  2. 进入数据集详情页,按页面指引申请权限或直接下载;
  3. 部分平台提供 SDK,例如:
    • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
    • ModelScope: pip install modelscope 后 modelscope download
    • 天池: 登录后页面提供直链下载
      以源站「数据下载/使用文档」页面为准。

数据说明

Conditions: Chronic Myelomonocytic Leukemia, Chronic Myeloid Leukemia, Polycythemia Vera, Hypereosinophilic Syndrome, Mastocytosis. Imatinib mesylate is a chemical compound that blocks a protein that is responsible for a certain form of leukemia. However, imatinib mesylate also blocks other important proteins that may be responsible for other blood diseases such as myeloproliferative disorders. Patients in this study will take 4 tablets of imatinib mesylate by mouth every day. Patients with HES will take 1 tablet daily to begin, and may go up to 4 tablets daily depending on response. Imatinib mesylate should be taken each morning at breakfast with a large glass of water. Bottles containing the tablets will be given to the patient every month. Unused supplies must be returned at the end of the study. Patients taking oral hydroxyurea to control their blood counts, can continue it during the first month of imatinib mesylate treatment, but must stop taking it from then on. After completing 2 months of therapy, response to imatinib mesylate will be evaluated. If the response is good, treatment with imatinib mesylate alone will be continued. If the response is not good, the dose of imatinib mesylate will be increased to 8 tablets daily (4 in the morning and 4 in the evening) or may be decreased to 3 tablets daily. This will be based on how the drug is tolerated. Treatment may be continued for up to one year, or as long as it is judged best to control the leukemia. Patients will be asked to visit their doctor for a physical exam and vital signs. The frequency of doctor visits will vary depending on physical condition. Blood tests (about 2 teaspoons) will be done once each year. The blood samples will be used for routine lab tests. A bone marrow sample will also be taken to check and measure cells related to the disease after 3 - 4 months, then every 3-6 months in the first year. If the initial bone marrow sample does not show disease, repeated bone marrows will not be done. This is an investigational study. Imatinib mesylate has been approved in CML for patients whose disease has not responded to inter

数据加载示例(图像类)

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据缺失?

依托陕西、四川两大基地,我们与超过十家三甲医院建立直接合作关系,覆盖合规授权、采集治理、专业标注、数据交付的全流程,为AI医疗团队提供即拿即用的高质量临床数据。

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