透明细胞肾细胞癌影像基因组学综合预后模型数据表4

数据集获取（Figshare）

• 源站标题：DataSheet_4_Exploration of an Integrative Prognostic Model of Radiogenomics Features With Underlying Gene Expression Patterns in Clear Cell Renal Cell Carcinoma.xlsx
• DOI：10.3389/fonc.2021.640881.s004
• 发布日期：2021-03-08
• 文件数：1 个
• 文件总体积：24.83 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_4_Exploration_of_an_Integrative_Prognostic_Model_of_Radiogenomics_Features_With_Underlying_Gene_Expression_Patterns_in_Clear_Cell_Renal_Cell_Carcinoma_xlsx/14177300

命令行下载

curl -L -o "DataSheet_4_Exploration of an Integrative Prognostic Model of Radiogenomics Features With Underlying Gene Expression Patterns in Clear Cell Renal Cell.xlsx" "https://ndownloader.figshare.com/files/26724620"

文件清单

• DataSheet_4_Exploration of an Integrative Prognostic Model of Radiogenomics Features With Underlying Gene Expression Patterns in Clear Cell Renal Cell.xlsx（24.83 KB）

文件总体积 24.83 KB（源站 API 实测）。

数据说明

BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies in urinary system, and radiomics has been adopted in tumor staging and prognostic evaluation in renal carcinomas. This study aimed to integrate image features of contrast-enhanced CT and underlying genomics features to predict the overall survival (OS) of ccRCC patients.
MethodWe extracted 107 radiomics features out of 205 patients with available CT images obtained from TCIA database and corresponding clinical and genetic information from TCGA database. LASSO-COX and SVM-RFE were employed independently as machine-learning algorithms to select prognosis-related imaging features (PRIF). Afterwards, we identified prognosis-related gene signature through WGCNA. The random forest (RF) algorithm was then applied to integrate PRIF and the genes into a combined imaging-genomics prognostic factors (IGPF) model. Furthermore, we constructed a nomogram incorporating IGPF and clinical predictors as the integrative prognostic model for ccRCC patients.
ResultsA total of four PRIF and four genes were identified as IGPF and were represented by corresponding risk score in RF model. The integrative IGPF model presented a better prediction performance than the PRIF model alone (average AUCs for 1-, 3-, and 5-year were 0.814 vs. 0.837, 0.74 vs. 0.806, and 0.689 vs. 0.751 in test set). Clinical characteristics including gender, TNM stage and IGPF were independent risk factors. The nomogram integrating clinical predictors and IGPF provided the best net benefit among the three models.
ConclusionIn this study we established an integrative prognosis-related nomogram model incorporating imaging-genomic features and clinical indicators. The results indicated that IGPF may contribute to a comprehensive prognosis assessment for ccRCC patients.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fonc.2021.640881.s004（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_4_Exploration_of_an_Integrative_Prognostic_Model_of_Radiogenomics_Features_With_Underlying_Gene_Expression_Patterns_in_Clear_Cell_Renal_Cell_Carcinoma_xlsx/14177300）。