与端粒酶逆转录酶（TERT）基因表达状态相关的人类转录模式的全癌症实验特征数据表1

数据集获取（Figshare）

• 源站标题：DataSheet1_Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expression status.ZIP
• DOI：10.3389/fgene.2024.1401100.s001
• 发布日期：2024-05-27
• 文件数：1 个
• 文件总体积：4.97 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet1_Pan-cancer_experimental_characteristic_of_human_transcriptional_patterns_connected_with_telomerase_reverse_transcriptase_TERT_gene_expression_status_ZIP/25906972

命令行下载

curl -L -o "DataSheet1_Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expres.ZIP" "https://ndownloader.figshare.com/files/46564450"

文件清单

• DataSheet1_Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expres.ZIP（4.97 MB）

文件总体积 4.97 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated in cancers where its expression is frequently associated with poor survival prognosis. Here we experimentally assessed the RNA sequencing expression patterns associated with TERT transcription in 1039 human cancer samples of 27 tumor types. We observed a bimodal distribution of TERT expression where ∼27% of cancer samples did not express TERT and the rest showed a bell-shaped distribution. Expression of TERT strongly correlated with 1443 human genes including 103 encoding transcriptional factor proteins. Comparison of TERT- positive and negative cancers showed the differential activation of 496 genes and 1975 molecular pathways. Therein, 32/38 (84%) of DNA repair pathways were hyperactivated in TERT+ cancers which was also connected with accelerated replication, transcription, translation, and cell cycle progression. In contrast, the level of 40 positive cell cycle regulator proteins and a set of epithelial-to-mesenchymal transition pathways was specific for the TERT- group suggesting different proliferation strategies for both groups of cancer. Our pilot study showed that the TERT+ group had ∼13% of cancers with C228T or C250T mutated TERT promoter. However, the presence of promoter mutations was not associated with greater TERT expression compared with other TERT+ cancers, suggesting parallel mechanisms of its transcriptional activation in cancers. In addition, we detected a decreased expression of L1 retrotransposons in the TERT+ group, and further decreased L1 expression in promoter mutated TERT+ cancers. TERT expression was correlated with 17 genes encoding molecular targets of cancer therapeutics and may relate to differential survival patterns of TERT- positive and negative cancers.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fgene.2024.1401100.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet1_Pan-cancer_experimental_characteristic_of_human_transcriptional_patterns_connected_with_telomerase_reverse_transcriptase_TERT_gene_expression_status_ZIP/25906972）。