SERPINE家族基因作为癌症预后和治疗反应生物标志物的泛癌分析数据表1

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• 源站标题：DataSheet1_Pan-cancer analysis of SERPINE family genes as biomarkers of cancer prognosis and response to therapy.PDF
• DOI：10.3389/fmolb.2023.1277508.s001
• 发布日期：2024-01-11
• 文件数：1 个
• 文件总体积：333.37 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet1_Pan-cancer_analysis_of_SERPINE_family_genes_as_biomarkers_of_cancer_prognosis_and_response_to_therapy_PDF/24979203

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• DataSheet1_Pan-cancer analysis of SERPINE family genes as biomarkers of cancer prognosis and response to therapy.PDF（333.37 KB）

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数据说明

Background: Serine protease inhibitor E (SERPINE) family genes participate in the tumor growth, cancer cell survival and metastasis. However, the SERPINE family members role in the prognosis and their clinical therapeutic potentials in various human cancer types have not been elaborately explored.
Methods: We preliminarily analyzed expression levels and prognostic values of SERPINE family genes, and investigated the correlation between SERPINEs expression and tumor microenvironment (TME), Stemness score, clinical characteristic, immune infiltration, tumor mutational burden (TMB), immune subtype, and drug sensitivity in pan-cancer, which based on updated public databases and integrated some bioinformatics analysis methods. In addition, we conducted the enrichment analysis of SERPINEs from DAVID and KOBAS databases.
Results: SERPINE1, SERPINE2, and SERPINE3 expression were upregulated in nine cancers, twelve cancers, and six cancers, respectively. The expression of SERPINE family genes was associated with the prognosis in several cancers from The Cancer Genome Atlas (TCGA). Furthermore, SERPINE family genes expression also had a significant relation to stromal and immune scores, and RNA stemness score and DNA stemness score in pan-cancer. SERPINE1 and SERPINE2 expression significantly increased in tumor advanced stage in colon adenocarcinoma (COAD). Results showed that SERPINE1 and SERPINE2 expression were negatively related with B cells and Monocytes, respectively. SERPINE2 expression had a significantly positive relation with B cells and Macrophages. In terms of TMB, SERPINE1, SERPINE2, and SERPINE3 were found to associated with TMB in seven cancers, fourteen cancers, and four cancers, respectively. Moreover, all SERPINE gene family members were significantly correlated with immune subtypes. SERPINE1 expression had a significantly positive or negative correlation with drug sensitivity.
Conclusion: The study indicated the great potential of SERPINE family genes as biomarkers for prognosis and provided valuable strategies for further investigation of SERPINE family genes as potential targets in cancer.

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CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fmolb.2023.1277508.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet1_Pan-cancer_analysis_of_SERPINE_family_genes_as_biomarkers_of_cancer_prognosis_and_response_to_therapy_PDF/24979203）。