基于抗菌肽的水凝胶用于预防医疗植入设备感染

数据集获取（Figshare）

• 源站标题：Antibacterial Peptide-Based Gel for Prevention of Medical Implanted-Device Infection
• DOI：10.1371/journal.pone.0145143
• 发布日期：2015-12-17
• 文件数：5 个
• 文件总体积：805.29 KB
• 源站页面：https://plos.figshare.com/articles/dataset/_Antibacterial_Peptide_Based_Gel_for_Prevention_of_Medical_Implanted_Device_Infection_/1624437

命令行下载

curl -L -o "S1_Fig.tif" "https://ndownloader.figshare.com/files/2608185"
curl -L -o "S2_Fig.tif" "https://ndownloader.figshare.com/files/2608186"
curl -L -o "S3_Fig.tif" "https://ndownloader.figshare.com/files/2608187"
curl -L -o "S4_Fig.tif" "https://ndownloader.figshare.com/files/2608188"
curl -L -o "S5_Fig.tif" "https://ndownloader.figshare.com/files/2608189"

文件清单

• S1_Fig.tif（126.45 KB）
• S2_Fig.tif（217.34 KB）
• S3_Fig.tif（210.28 KB）
• S4_Fig.tif（134.63 KB）
• S5_Fig.tif（116.60 KB）

文件总体积 805.29 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Implanted medical devices are prone to infection. Designing new strategies to reduce infection and implant rejection are an important challenge for modern medicine. To this end, in the last few years many hydrogels have been designed as matrices for antimicrobial molecules destined to fight frequent infection found in moist environments like the oral cavity. In this study, two types of original hydrogels containing the antimicrobial peptide Cateslytin have been designed. The first hydrogel is based on alginate modified with catechol moieties (AC gel). The choice of these catechol functional groups which derive from mussel’s catechol originates from their strong adhesion properties on various surfaces. The second type of gel we tested is a mixture of alginate catechol and thiol-terminated Pluronic (AC/PlubisSH), a polymer derived from Pluronic, a well-known biocompatible polymer. This PlubisSH polymer has been chosen for its capacity to enhance the cohesion of the composition. These two gels offer new clinical uses, as they can be injected and jellify in a few minutes. Moreover, we show these gels strongly adhere to implant surfaces and gingiva. Once gelled, they demonstrate a high level of rheological properties and stability. In particular, the dissipative energy of the (AC/PlubisSH) gel detachment reaches a high value on gingiva (10 J.m-2) and on titanium alloys (4 J.m-2), conferring a strong mechanical barrier. Moreover, the Cateslytin peptide in hydrogels exhibited potent antimicrobial activities against P. gingivalis, where a strong inhibition of bacterial metabolic activity and viability was observed, indicating reduced virulence. Gel biocompatibility tests indicate no signs of toxicity. In conclusion, these new hydrogels could be ideal candidates in the prevention and/or management of periimplant diseases.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0145143（source: https://plos.figshare.com/articles/dataset/_Antibacterial_Peptide_Based_Gel_for_Prevention_of_Medical_Implanted_Device_Infection_/1624437）。