病毒感染下固醇生物合成基因新生mRNA合成的测量

资源简介

病毒感染下固醇生物合成基因新生mRNA合成的测量

【数据集背景】

本数据集源站标题为《Measurement of de novo mRNA synthesis of sterol biosynthesis genes upon viral infection.》。配套论文《Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis》发表于 PLoS Biology（2011），DOI：10.1371/journal.pbio.1000598。源站首次发布：2011-03-08。

【数据内容】

源站原始描述：Wild Type or Tyk2−/− BMDM were infected with mCMV at an MOI of 1 for 1 h. De novo RNA was labeled between 360 and 390 min post-infection, isolated, and hybridized to Affymetrix Gene 1.0 ST microarrays (Materials and Methods). After scanning and data capture, gene expression in mock-infected or infected cells was analyzed, and for the purposes of presentation, gene expression values from control (mock infected) BMDM (black) were adjusted to a value of 1. Values for expression in infected cells (w…

【数据结构与技术规格】

文件数 1 个，合计 2.24 MB。Figure 8.tif：image/tiff，2.24 MB。数据集 DOI：10.1371/journal.pbio.1000598.g008。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Microbiology、Genetics、Molecular Biology、Physiology。主题标签：type 1 IFN、sterol pathway、interferon family members、sterol biosynthesis、metabolite rescue experiments、modulating lipid metabolism、srebf 2 gene transcription、Sterol Biosynthesis Little、IL 6. Quantitative analysis、IFN β treatment。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Microbiology、Genetics、Molecular Biology、Physiology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Measurement_of_de_novo_mRNA_synthesis_of_sterol_biosynthesis_genes_upon_viral_infection_/463986

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Blanc, Mathieu; Yuan Hsieh, Wei; A. Robertson, Kevin; Watterson, Steven; Shui, Guanghou; Lacaze, Paul; et al. (2016). Measurement of de novo mRNA synthesis of sterol biosynthesis genes upon viral infection.. PLOS Biology. Dataset

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。