髓系细胞来源的缺氧诱导因子1α对烟曲霉肺部感染的保护作用研究数据集

资源简介

髓系细胞来源的缺氧诱导因子1α对烟曲霉肺部感染的保护作用研究数据集

【数据集背景】

本数据集源站标题为《Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection》。配套论文《Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection》发表于 PLoS Pathogens（2014），DOI：10.1371/journal.ppat.1004378。源站首次发布：2014-09-25。

【数据内容】

源站原始描述：Hypoxia inducible factor 1α (HIF1α) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen. Previous work established that generation of hypoxic microenvironments occurs within the lung during infection with the human fungal pathogen Aspergillus fumigatus. Here we demonstrate that A. fumigatus stabilizes HIF1α protein early after pulmonary challenge that is inhibited by treatment of mice with the steroid triamcin…

【数据结构与技术规格】

文件数 5 个，合计 8.11 MB。Figure_S1.tif：image/tiff，69.11 KB。数据集 DOI：10.1371/journal.ppat.1004378。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：pathogen Aspergillus fumigatus、survival、HIF 1α mice、neutrophil、Pulmonary Aspergillus fumigatus Infection Hypoxia inducible factor 1α、chemokine CXCL 1、HIF 1α protein、infection、kc、HIF 1α。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Myeloid_Derived_Hypoxia_Inducible_Factor_1_alpha_Is_Required_for_Protection_against_Pulmonary_Aspergillus_fumigatus_Infection/1182161

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：M. Shepardson, Kelly; Jhingran, Anupam; Caffrey, Alayna; J. Obar, Joshua; T. Suratt, Benjamin; L. Berwin, Brent; et al. (2016). Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection. PLOS Pathogens. Dataset

【使用注意】

· 源站最后修改于 2023-06-03，引用时请注意版本时效。