测量突变对细胞色素P450 21A2的结构影响：与先天性肾上腺皮质增生症相关的主要类固醇21-羟化酶

资源简介

测量突变对细胞色素P450 21A2的结构影响：与先天性肾上腺皮质增生症相关的主要类固醇21-羟化酶

【数据集背景】

本数据集源站标题为《Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia》。配套论文《Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia》发表于 Journal of Biomolecular Structure and Dynamics（2019），DOI：10.1080/07391102.2019.1607560。项目资助方：The authors appreciate the support of the National Council for Scientific and Technological Development (CNPq) and Federal University of Pará (UFPA).。源站首次发布：2020-03-12。

【数据内容】

源站原始描述：Congenital adrenal hyperplasia is an inherited autosomal recessive disorder related to deficient cortisol synthesis. The deficiency of steroid 21-hydroxylase (cytochrome P450 21A2), an enzyme involved in cortisol synthesis, is responsible for ∼95% of cases of congenital adrenal hyperplasia. This metabolic disease exhibits three clinical forms: salt-wasting, simple virilizing, and non-classical form, which are divided according to the degree of severity. In the present study, structural and mutat…

【数据结构与技术规格】

文件数 2 个，合计 1.55 MB。tbsd_a_1607560_sm1849.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，1.32 MB。tbsd_a_1607560_sm1848.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，230.76 KB。数据集 DOI：10.6084/m9.figshare.8058887.v2。

【主题与分类】

源站学科分类：Biophysics、Biochemistry、Genetics、Chemical Sciences not elsewhere classified、Biological Sciences not elsewhere classified、Computational Biology。主题标签：Adrenal hyperplasia、mutations、CYP21A2、molecular dynamics、21-hydroxylase。

【适用方向】

源站学科分类标注为 Biophysics、Biochemistry、Genetics、Chemical Sciences not elsewhere classified、Biological Sciences not elsewhere classified、Computational Biology。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/Measuring_the_structural_impact_of_mutations_on_cytochrome_P450_21A2_the_major_steroid_21-hydroxylase_related_to_congenital_adrenal_hyperplasia/8058887

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia. Taylor & Francis. Cruz, Jorddy Neves; da Costa, Kauê Santana; de Carvalho, Tarcísio André Amorim; de Alencar, Nelson Alberto Nascimento

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。