SIV感染猕猴中CD4耗竭导致巨噬细胞和小胶质细胞感染及感染细胞快速周转

资源简介

SIV感染猕猴中CD4耗竭导致巨噬细胞和小胶质细胞感染及感染细胞快速周转

【数据集背景】

本数据集源站标题为《CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells》。配套论文《CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells》发表于 PLoS Pathogens（2014），DOI：10.1371/journal.ppat.1004467。源站首次发布：2014-10-30。

【数据内容】

源站原始描述：In rhesus macaques (RMs), experimental depletion of CD4+ T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4+ T-cells prior to SIVmac251 infection and investigate the sources of the increased viral burden and the lifespan of productively infected cells. CD4-depleted animals showed (i) set-point viral load two-logs higher than controls; (ii) macrophages const…

【数据结构与技术规格】

文件数 4 个，合计 2.56 MB。Figure_S1.tif：image/tiff，1.34 MB。Figure_S2.tif：image/tiff，428.54 KB。Figure_S3.tif：image/tiff，738.90 KB。数据集 DOI：10.1371/journal.ppat.1004467。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：SIV vRNA、SIVmac 251 infection、rm、lymph node、Rapid Turnover、Microglial cells、control SIV replication、4r、Infected Cells、CD 4 depletion。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_CD4_Depletion_in_SIV_Infected_Macaques_Results_in_Macrophage_and_Microglia_Infection_with_Rapid_Turnover_of_Infected_Cells_/1223230

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Micci, Luca; Alvarez, Xavier; I. Iriele, Robin; M. Ortiz, Alexandra; S. Ryan, Emily; S. McGary, Colleen; et al. (2016). CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells. PLOS Pathogens. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。