RNA聚合酶I和III亚基Polr1c与Polr1d在颅面发育及斑马鱼Treacher Collins综合征模型中的作用

资源简介

RNA聚合酶I和III亚基Polr1c与Polr1d在颅面发育及斑马鱼Treacher Collins综合征模型中的作用

【数据集背景】

本数据集源站标题为《The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome》。配套论文《The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome》发表于 PLOS Genetics（2016），DOI：10.1371/journal.pgen.1006187。源站首次发布：2016-07-22。

【数据内容】

源站原始描述：Ribosome biogenesis is a global process required for growth and proliferation of all cells, yet perturbation of ribosome biogenesis during human development often leads to tissue-specific defects termed ribosomopathies. Transcription of the ribosomal RNAs (rRNAs) by RNA polymerases (Pol) I and III, is considered a rate limiting step of ribosome biogenesis and mutations in the genes coding for RNA Pol I and III subunits, POLR1C and POLR1D cause Treacher Collins syndrome, a rare congenital craniof…

【数据结构与技术规格】

文件数 9 个，合计 97.59 MB。S3 Fig.TIF：image/tiff，4.66 MB。数据集 DOI：10.1371/journal.pgen.1006187。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Biological Sciences not elsewhere classified。主题标签：Treacher Collins Syndrome Ribosome biogenesis、POLR 1D cause Treacher Collins syndrome、III Subunits Polr 1c、neuroepithelial cell death、ribosome biogenesis、polr 1d loss-of-function results、Tp 53-dependent neuroepithelial cell death、RNA polymerase subunits、polr 1d mutants、polr 1d。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Biological Sciences not elsewhere classified。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/The_Roles_of_RNA_Polymerase_I_and_III_Subunits_Polr1c_and_Polr1d_in_Craniofacial_Development_and_in_Zebrafish_Models_of_Treacher_Collins_Syndrome/3501374

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：E. Noack Watt, Kristin; Achilleos, Annita; Neben, Cynthia L.; E. Merrill, Amy; A. Trainor, Paul (2016). The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。