脊髓损伤患者急慢性伤口和压力溃疡MPPT免疫疗法数据表

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• 源站标题：Data_Sheet_1_Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal cord injuries: non-interventional study of MPPT passive immunotherapy delivered via telemedicine in community care.docx
• DOI：10.3389/fmed.2023.1279100.s001
• 发布日期：2024-01-05
• 文件数：1 个
• 文件总体积：144.62 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Stable_closure_of_acute_and_chronic_wounds_and_pressure_ulcers_and_control_of_draining_fistulas_from_osteomyelitis_in_persons_with_spinal_cord_injuries_non-interventional_study_of_MPPT_passive_immunotherapy_delivered_via_teleme/24946983

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• Data_Sheet_1_Stable closure of acute and chronic wounds and pressure ulcers and control of draining fistulas from osteomyelitis in persons with spinal.docx（144.62 KB）

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数据说明

BackgroundMicropore particle technology (MPPT) is a topical wound treatment. It is a passive immunotherapy, acting via the skin and wound microbiome without the use of antimicrobial action. In a general patient population, it removed wound infections 60% and initiated tissue regeneration 50% quicker than antibiotics and antiseptics. As MPPT supports the immune system, the aim was to confirm that MPPT is also effective in immunocompromised individuals. People with spinal cord injury (SCI) are immunodeficient due to their injury and not an underlying disease and recruit 50% fewer immune cells to an injury. The study, therefore, determined the efficacy, safety, health economics, and sustainability of MPPT in acute and chronic wounds and pressure ulcers in this patient population.
MethodsPressure ulcers in SCI persons are an orphan indication, patient variability is high, and ICH E10 excludes comparators due to ethical concerns. The study design was, therefore, a single-arm, non-interventional, observational, post-market surveillance study of MPPT for treating wounds and pressure ulcers and removing soft tissue infection in connection with draining fistulas in SCI persons. The study was based on telemedicine in community care.
ResultsThe study included 44 wounds. All acute and chronic grade 1–4 wounds and pressure ulcers reached stable closure. In wounds acting as fistulas draining from an underlying, primary focus of infection, e.g., osteomyelitis, MPPT removed the soft tissue infection in approx. 2.5 months and supported regeneration, considerably reducing fistula sizes. Compared to standard care, per-wound cost savings were 51 to 94% depending on wound grade and age, and substantial nursing resources were freed up. The telemedicine approach was well received by participants and supported independence and self-care. The use of antimicrobials, plastics, and synthetic polymers was essentially eliminated. MPPT did not require bed rest.
ConclusionThe study confirmed that MPPT is safe and effective in treating acute and chronic wounds in immunocompetent and immunocompromised individuals, including wounds with antimicrobial-resistant infections. MPPT also removes soft t

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CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fmed.2023.1279100.s001（source: https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Stable_closure_of_acute_and_chronic_wounds_and_pressure_ulcers_and_control_of_draining_fistulas_from_osteomyelitis_in_persons_with_spinal_cord_injuries_non-interventional_study_of_MPPT_passive_immunotherapy_delivered_via_teleme/24946983）。