Clade 2.3.4.4b H5N1 甲型流感病毒在人呼吸道模型中展现高感染性

数据集获取

源站：https://ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307315

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b are currently spreading widely among poultry, cattle, and other mammals in the United States, raising concern for zoonotic transmission and pandemic potential. To investigate the pathogenicity and host response of the newly emerged A/Cattle/Texas/063224-24-1/2024 (H5N1b/2024) strain in comparison to reference viruses, we performed bulk RNA sequencing of primary human respiratory models, including ex vivo alveolar lung tissue (aHuLu), organoid-derived bronchial epithelium (brEp), and 3D nasal air-liquid interface epithelium (nALI). Infections were carried out in parallel with H5N1/2004 (clade 1), H3N2/1999 (seasonal influenza A), and H5N8/2016 (low pathogenic avian influenza). Differential gene expression analysis was performed with DESeq2, including donor as a covariate. The dataset provides genome-wide transcriptional profiles at 24 h post-infection, enabling comparative analysis of viral replication, host immune activation, and tissue-specific responses across human respiratory compartments. These data support the use of physiologically relevant primary human models for assessing zoonotic risk of emerging influenza A viruses.

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。