头晕/眩晕多层次遗传调控多组学数据集

数据集获取（Figshare）

• 源站标题：A systems biology framework uncovers multi-level genetic regulation of dizziness/vertigo through eQTL–GWAS integration and single-cell analysis
• DOI：10.6084/m9.figshare.31264783.v2
• 发布日期：2026-02-12
• 文件数：4 个
• 文件总体积：37.21 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/A_Systems_Biology_Framework_Uncovers_Multi-Level_Genetic_Regulation_of_Dizziness_vertigo_Through_eQTL_GWAS_Integration_and_Single-Cell_Analysis/31264783

命令行下载

curl -L -o "ines_a_2627258_sm7501.pdf" "https://ndownloader.figshare.com/files/61659529"
curl -L -o "ines_a_2627258_sm7500.pdf" "https://ndownloader.figshare.com/files/61659532"
curl -L -o "ines_a_2627258_sm7499.xlsx" "https://ndownloader.figshare.com/files/61659535"
curl -L -o "ines_a_2627258_sm7498.pdf" "https://ndownloader.figshare.com/files/61659538"

文件清单

• ines_a_2627258_sm7501.pdf（5.51 KB）
• ines_a_2627258_sm7500.pdf（7.17 KB）
• ines_a_2627258_sm7499.xlsx（19.22 KB）
• ines_a_2627258_sm7498.pdf（5.31 KB）

文件总体积 37.21 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Dizziness/vertigo is a multifactorial neurological disorder with complex ge-netic and cellular bases, yet its molecular mechanisms remain unclear. Understanding how gene regulation contributes to dizziness/vertigo may reveal novel neurobiological and therapeutic insights.
We established a multi-omics integrative framework combining genome-wide association study (GWAS) data with expression quantitative trait loci (eQTL) from brain single-cell types, CD4+ T cells, oneK1K immune cells, and plasma. Two-sample Mendelian randomization (MR) and colocalization analyses were applied to identify causal genes. Single-cell RNA sequencing (scRNA-seq) of the auditory nerve was used to as-sess cell type–specific expression, intercellular communication, and pseudotime dynam-ics. Gene–gene interaction and drug–target networks were further constructed to identify potential therapeutic candidates.
Six key genes—Activin A Receptor Type 2 A (ACVR2A), Phospholipid Transfer Protein (PLTP), Androgen Dependent TFPI Regulating Protein (ADTRP), Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like (MTHFD1L), Collagen Type VII Alpha 1 Chain (COL7A1), and Pantothenate Kinase 4 (PANK4)—showed strong causal and colocalization evidence for dizziness/vertigo. Single-cell analysis revealed distinct cell type–specific expression, with fibroblasts and adipocytes playing central roles in signaling and gene regulation. Pseudo-time trajectories indicated coordinated upregulation of ACVR2A, MTHFD1L, PANK4, and PLTP during later developmental stages. Interaction network analysis positioned these genes as major hubs, and DrugBank screening identified Sotatercept as a promising candidate targeting ACVR2A.
This integrative analysis links gene expres-sion regulation to dizziness/vertigo across neuroimmune and metabolic systems. The findings uncover coordinated molecular pathways underlying disease susceptibility and highlight novel therapeutic targets, providing a foundation for precision treatment strate-gies.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.31264783.v2（source: https://tandf.figshare.com/articles/dataset/A_Systems_Biology_Framework_Uncovers_Multi-Level_Genetic_Regulation_of_Dizziness_vertigo_Through_eQTL_GWAS_Integration_and_Single-Cell_Analysis/31264783）。