类淋巴系统功能障碍中的精准医学靶点：基因组与分子视角

数据集获取（Figshare）

• 源站标题：Precision Medicine
  Targets in Glymphatic System Dysfunction:
  A Genomic and Molecular Perspective
• DOI：10.1021/acschemneuro.5c00962.s002
• 发布日期：2026-03-24
• 文件数：1 个
• 文件总体积：193.59 KB
• 源站页面：https://acs.figshare.com/articles/dataset/Precision_Medicine_Targets_in_Glymphatic_System_Dysfunction_A_Genomic_and_Molecular_Perspective/31843007

命令行下载

curl -L -o "cn5c00962_si_002.zip" "https://ndownloader.figshare.com/files/63055619"

文件清单

• cn5c00962_si_002.zip（193.59 KB）

文件总体积 193.59 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

The genetic basis of traits linked to glymphatic system
dysfunction
(GSd) remains poorly understood. Using Genomic Structural Equation
Modeling (Genomic-SEM) and multiple post Genome-Wide Association Studies
(GWAS) methods, we identified four potentially genome-wide significant
loci and one significant gene (Transmembrane protein 106B, TMEM106B).
Transcriptome-wide analyses identified susceptibility gene signaling
loci and related component information, and a multigene score assessed
GSd risk across chromosomes. Although TMEM106B is linked to neurological
disorders, the molecular mechanisms of its missense variants remain
unclear. We innovatively integrated AI-powered high-precision structural
prediction, protein-model-based dynamics simulation, and thermodynamic
stability analysis. This systematically revealed, for the first time,
how the TMEM106B mutations (T185I, T185N, and T185S) potentially affect
the glymphatic system: by disrupting protein structural integrity
and influencing dynamic behavior, ultimately impairing function. Our
study provides the first panoramic view of GSd’s genetic structure,
offering a vital theoretical basis for understanding the glymphatic
system dysfunction pathogenesis and identifying new targets for precision
medicine and pharmacological interventions.

许可

CC BY-NC 4.0

引用

学术使用请引用 DOI 10.1021/acschemneuro.5c00962.s002（source: https://acs.figshare.com/articles/dataset/Precision_Medicine_Targets_in_Glymphatic_System_Dysfunction_A_Genomic_and_Molecular_Perspective/31843007）。