病例报告：单细胞测序揭示共表达TCR αβ和γ链的未分类T细胞淋巴瘤亚型数据表2
一例未分类T细胞淋巴瘤患者PBMC和骨髓单细胞RNA联合TCR测序数据，揭示恶性T细胞共表达TCR αβ和γ链及潜在治疗靶点。
基本信息
资源简介
病例报告：单细胞测序揭示共表达TCR αβ和γ链的未分类T细胞淋巴瘤亚型数据表2
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 1 个文件、合计 9.23 KB，主题涵盖 TCR - T cell receptor、T cell lymphoma、single cell、single cell RNA seq、single cell TCR sequencing，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx》。配套论文《Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression》发表于 期刊（2022），DOI：10.1101/2022.01.17.476575。源站首次发布：2023-05-31。
【数据内容】
源站原始描述：BackgroundT cell lymphomas (TCL) are a group of heterogeneous diseases with over 40 subtypes. In this study, we identified a novel TCL subtype which was featured by a unique T cell receptor (TCR) presentation, α, β and γ chains were co-existing in a single malignant T cell. Case presentationA 45-year-old male patient was diagnosed T cell lymphoma after 2-month of abdominal distension and liver enlargement. Combining histology review, PET-CT scanning and immunophenotyes, the patient was not class…
【数据结构与技术规格】
文件数 1 个，合计 9.23 KB。DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，9.23 KB。数据集 DOI：10.3389/fimmu.2023.1184383.s002。
【主题与分类】
源站学科分类：Transplantation Immunology、Tumour Immunology、Immunology not elsewhere classified、Immunology、Veterinary Immunology、Animal Immunology。主题标签：TCR - T cell receptor、T cell lymphoma、single cell、single cell RNA seq、single cell TCR sequencing。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Case_Report_An_unclassified_T_cell_lymphoma_subtype_with_co-expression_of_TCR_and_chains_revealed_by_single_cell_sequencing_xlsx/23269136
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Song, Wei; Wang, Gang; Wang, Cheng; Liu, Lulu; Zhang, Liming; Zhang, Ruoyu; et al. (2023). DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx. Frontiers. Dataset
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使用方式
数据集获取（Figshare）
- 源站标题：DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx
- DOI：10.3389/fimmu.2023.1184383.s002
- 发布日期：2023-05-31
- 文件数：1 个
- 文件总体积：9.23 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Case_Report_An_unclassified_T_cell_lymphoma_subtype_with_co-expression_of_TCR_and_chains_revealed_by_single_cell_sequencing_xlsx/23269136
命令行下载
curl -L -o "DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx" "https://ndownloader.figshare.com/files/41012690"
文件清单
DataSheet_2_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx（9.23 KB）
文件总体积 9.23 KB（源站 API 实测）。
数据说明
BackgroundT cell lymphomas (TCL) are a group of heterogeneous diseases with over 40 subtypes. In this study, we identified a novel TCL subtype which was featured by a unique T cell receptor (TCR) presentation, α, β and γ chains were co-existing in a single malignant T cell.
Case presentationA 45-year-old male patient was diagnosed T cell lymphoma after 2-month of abdominal distension and liver enlargement. Combining histology review, PET-CT scanning and immunophenotyes, the patient was not classified to any existing TCL subtypes. To better understand this unclassified TCL case, we performed single cell RNA sequencing paired with TCR sequencing on the patient’s PBMC and bone marrow samples. To our surprise, we identified that the malignant T cells had a very rare TCR combination, by expressing two α chains, one β chain and one γ chain simultaneously. We further studied the molecular pathogenesis and tumor cell heterogeneity of this rare TCL subtype. A set of potential therapeutic targets were identified from the transcriptome data, such as CCL5, KLRG1 and CD38.
ConclusionsWe identified the first TCL case co-expressing α, β and γ chains and dissected its molecular pathogenesis, providing valuable information for precision medicine options for this novel TCL subtype.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fimmu.2023.1184383.s002（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Case_Report_An_unclassified_T_cell_lymphoma_subtype_with_co-expression_of_TCR_and_chains_revealed_by_single_cell_sequencing_xlsx/23269136）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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