中国卵巢癌患者癌症易感基因突变特征表5

数据集获取（Figshare）

• 源站标题：Table_5_Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients.xlsx
• DOI：10.3389/fonc.2024.1395818.s016
• 发布日期：2024-05-16
• 文件数：1 个
• 文件总体积：26.62 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_5_Mutation_characteristics_of_cancer_susceptibility_genes_in_Chinese_ovarian_cancer_patients_xlsx/25834735

命令行下载

curl -L -o "Table_5_Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients.xlsx" "https://ndownloader.figshare.com/files/46361419"

文件清单

• Table_5_Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients.xlsx（26.62 KB）

文件总体积 26.62 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

IntroductionThe association between mutations in susceptibility genes and the occurrence of ovarian cancer has been extensively studied. Previous research has primarily concentrated on genes involved in the homologous recombination repair pathway, particularly BRCA1 and BRCA2. However, a wider range of genes related to the DNA damage response pathways has not been fully explored.
MethodsTo investigate the mutation characteristics of cancer susceptibility genes in the Chinese ovarian cancer population and the associations between gene mutations and clinical data, this study initially gathered a total of 1171 Chinese ovarian cancer samples and compiled a dataset of germline mutations in 171 genes.
ResultsIn this study, it was determined that MC1R and PRKDC were high-frequency ovarian cancer susceptibility genes in the Chinese population, exhibiting notable distinctions from those in European and American populations; moreover high-frequency mutation genes, such as MC1R: c.359T>C and PRKDC: c.10681T>A, typically had high-frequency mutation sites. Furthermore, we identified c.8187G>T as a characteristic mutation of BRCA2 in the Chinese population, and the CHEK2 mutation was significantly associated with the early onset of ovarian cancer, while the CDH1 and FAM175A mutations were more prevalent in Northeast China. Additionally, Fanconi anemia pathway-related genes were significantly associated with ovarian carcinogenesis.
ConclusionIn summary, this research provided fundamental data support for the optimization of ovarian cancer gene screening policies and the determination of treatment, and contributed to the precise intervention and management of patients.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fonc.2024.1395818.s016（source: https://frontiersin.figshare.com/articles/dataset/Table_5_Mutation_characteristics_of_cancer_susceptibility_genes_in_Chinese_ovarian_cancer_patients_xlsx/25834735）。