放射质量对具有不同分子谱和不同α/β比的卵巢癌细胞系生存、侵袭和迁移的影响：代表意大利卵巢癌多中心试验（MITO）组的体外研究
卵巢癌细胞系在光子、质子、碳离子照射后的生存、迁移和侵袭实验数据，用于评估放射质量对肿瘤表型的影响。
基本信息
资源简介
放射质量对具有不同分子谱和不同α/β比的卵巢癌细胞系生存、侵袭和迁移的影响：代表意大利卵巢癌多中心试验（MITO）组的体外研究
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 2 个文件、合计 38.28 KB，主题涵盖 Ovarian cancer、BRCA、photon beam radiotherapy、carbon ion radiotherapy、proton beam radiotherapy，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Quality of radiation shapes survival, invasiveness, and migration in ovarian cancer cell lines with different molecular profiles and varying alpha/beta ratios: an in vitro study on behalf of the Multicenter Italian Trials in Ovarian Cancer (MITO) group》。配套论文《Quality of radiation shapes survival, invasiveness, and migration in ovarian cancer cell lines with different molecular profiles and varying alpha/beta ratios: an in vitro study on behalf of the Multicenter Italian Trials in Ovarian Cancer (MITO) group》发表于 International Journal of Radiation Biology（2025），DOI：10.1080/09553002.2025.2531909。源站首次发布：2025-08-06。
【数据内容】
源站原始描述：The results of radiotherapy (RT) in oligometastatic ovarian cancers (OCs) lead to the query whether it is possible to stratify patients based on tumor hallmarks to ensure the best-personalized RT treatment. To address this question, we designed a preclinical study to evaluate the effects of high and low linear energy transfer (LET) radiation while considering molecular features and alpha/beta ratios of different OC cell lines. Exponentially growing human OVSAHO, OVCAR8, COV362, and OVCAR3 cells…
【数据结构与技术规格】
文件数 2 个，合计 38.28 KB。irab_a_2531909_sm9739.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，19.36 KB。irab_a_2531909_sm9738.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，18.92 KB。数据集 DOI：10.6084/m9.figshare.29847515.v1。
【主题与分类】
源站学科分类：Physical Sciences not elsewhere classified、Cell Biology、Biotechnology、Chemical Sciences not elsewhere classified、Ecology、Biological Sciences not elsewhere classified。主题标签：Ovarian cancer、BRCA、photon beam radiotherapy、carbon ion radiotherapy、proton beam radiotherapy。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://tandf.figshare.com/articles/dataset/Quality_of_radiation_shapes_survival_invasiveness_and_migration_in_ovarian_cancer_cell_lines_with_different_molecular_profiles_and_varying_alpha_beta_ratios_an_in_vitro_study_on_behalf_of_the_Multicenter_Italian_Trials_in_Ovarian_Cancer_MIT/29847515
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Quality of radiation shapes survival, invasiveness, and migration in ovarian cancer cell lines with different molecular profiles and varying alpha/beta ratios: an in vitro study on behalf of the Multicenter Italian Trials in Ovarian Cancer (MITO) group. Taylor & Francis. Barcellini, Amelia; Charalam…
【使用注意】
· 源站最后修改于 2025-10-22，引用时请注意版本时效。
下载信息
注册下载
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暂未开放公开下载
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提供高速下载与技术交付服务（收技术服务费，非数据销售）
暂未开放当前数据集主要来源为 Kaggle 公开托管，完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取（Figshare）
- 源站标题：Quality of radiation shapes survival, invasiveness, and migration in ovarian cancer cell lines with different molecular profiles and varying alpha/beta ratios: an in vitro study on behalf of the Multicenter Italian Trials in Ovarian Cancer (MITO) group
- DOI：10.6084/m9.figshare.29847515.v1
- 发布日期：2025-08-06
- 文件数：2 个
- 文件总体积：38.28 KB
- 源站页面：https://tandf.figshare.com/articles/dataset/Quality_of_radiation_shapes_survival_invasiveness_and_migration_in_ovarian_cancer_cell_lines_with_different_molecular_profiles_and_varying_alpha_beta_ratios_an_in_vitro_study_on_behalf_of_the_Multicenter_Italian_Trials_in_Ovarian_Cancer_MIT/29847515
命令行下载
curl -L -o "irab_a_2531909_sm9739.docx" "https://ndownloader.figshare.com/files/56975306"
curl -L -o "irab_a_2531909_sm9738.docx" "https://ndownloader.figshare.com/files/56975309"
文件清单
irab_a_2531909_sm9739.docx（19.36 KB）irab_a_2531909_sm9738.docx（18.92 KB）
文件总体积 38.28 KB（源站 API 实测）。
数据说明
The results of radiotherapy (RT) in oligometastatic ovarian cancers (OCs) lead to the query whether it is possible to stratify patients based on tumor hallmarks to ensure the best-personalized RT treatment. To address this question, we designed a preclinical study to evaluate the effects of high and low linear energy transfer (LET) radiation while considering molecular features and alpha/beta ratios of different OC cell lines.
Exponentially growing human OVSAHO, OVCAR8, COV362, and OVCAR3 cells cultured in T-25 and T-75 flasks were exposed to different single physical doses of photons, protons, and carbon ion (CIRT) irradiation. We assessed ovarian cells’ in vitro response using clonogenic survival (fitted using LQ model), migration by Boyden chamber assay, and invasion through BioCoat Matrigel invasion assay.
Following photon irradiation, OVCAR3 was the most radioresistant and OVCAR8 the most radiosensitive cell line. OC cell migration decreased in a dose-dependent manner after irradiation, with CIRT showing the strongest effect, evident by the α/β ratio. The number of invading cells decreased following irradiation with all types. However, the greatest reduction was seen in CIRT, particularly at higher α/β ratios. Proton irradiation demonstrated similar potential to photons but did not match the effects of carbon ions in terms of survival, migration, and invasion. Conclusion: CIRT markedly reduced survival, migration, and invasion of OC cells, particularly in BRCA wild-type OVCAR3 emphasizing its potential to improve local control and lower metastasis risk. This preliminary study serves as a foundation for developing personalized clinical radiation strategies to treat oligometastatic OCs.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.6084/m9.figshare.29847515.v1（source: https://tandf.figshare.com/articles/dataset/Quality_of_radiation_shapes_survival_invasiveness_and_migration_in_ovarian_cancer_cell_lines_with_different_molecular_profiles_and_varying_alpha_beta_ratios_an_in_vitro_study_on_behalf_of_the_Multicenter_Italian_Trials_in_Ovarian_Cancer_MIT/29847515）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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