Serpine2/PN-1 是髓母细胞瘤恶性进展中前病变增殖性扩张所必需的

资源简介

Serpine2/PN-1 是髓母细胞瘤恶性进展中前病变增殖性扩张所必需的

【数据集背景】

本数据集源站标题为《Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma》。配套论文《Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0124870。源站首次发布：2015-04-22。

【数据内容】

源站原始描述：Background Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans. Transcriptome analysis has identified four major medulloblastoma subgroups. One of them, the Sonic hedgehog (SHH) subgroup, is caused by aberrant Hedgehog signal transduction due to mutations in the Patched1 (PTCH1) receptor or downstream effectors. Mice carrying a Patched-1 null allele (Ptch1∆/+) are a goo…

【数据结构与技术规格】

文件数 7 个，合计 11.60 MB。S2_Fig.tif：image/tiff，3.05 MB。S3_Fig.tif：image/tiff，3.57 MB。数据集 DOI：10.1371/journal.pone.0124870。

【主题与分类】

源站学科分类：Uncategorised。主题标签：mouse medulloblastoma cells、SERPINE、medulloblastoma DAOY cells、wnt、pn、SHH subgroup medulloblastomas、Hedgehog pathway activity.ResultsTranscriptome analysis、ptch、Hedgehog signal transduction、childhood brain tumors。

【适用方向】

源站学科分类标注为 Uncategorised。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Serpine2_PN_1_Is_Required_for_Proliferative_Expansion_of_Pre_Neoplastic_Lesions_and_Malignant_Progression_to_Medulloblastoma_/1390713

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Vaillant, Catherine; Valdivieso, Paola; Nuciforo, Sandro; Kool, Marcel; Schwarzentruber-Schauerte, Alexandra; Méreau, Hélène; et al. (2016). Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-04，引用时请注意版本时效。