染色体1大片段缺失导致斑马鱼恶性外周神经鞘瘤和癌的GFP标记数据集

资源简介

染色体1大片段缺失导致斑马鱼恶性外周神经鞘瘤和癌的GFP标记数据集

【数据集背景】

本数据集源站标题为《A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish》。配套论文《A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0145178。源站首次发布：2016-01-05。

【数据内容】

源站原始描述：Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas, characterized by complex karyotypes. The molecular bases of such malignancy are poorly understood and efficient targeted molecular therapies are currently lacking. Here we describe a novel zebrafish model of MPNSTs, represented by the transgenic mutant line Tg(-8.5nkx2.2a:GFP)ia2. ia2 homozygous animals displayed embryonic lethality by 72 hpf, while the heterozygotes develop visible tumor masses with hi…

【数据结构与技术规格】

文件数 4 个，合计 24.64 MB。S1_Fig.tif：image/tiff，2.40 MB。S2_Table.pdf：application/pdf，2.98 MB。数据集 DOI：10.1371/journal.pone.0145178。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：tumor masses、cancer development、protein S 6 gene、GFP tag、animal model、vntr、chromosome 1.、15.2 Mb、tg、nerve sheath tumors。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_A_GFP_Tagged_Gross_Deletion_on_Chromosome_1_Causes_Malignant_Peripheral_Nerve_Sheath_Tumors_and_Carcinomas_in_Zebrafish_/1628949

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Astone, Matteo; Pizzi, Marco; Peron, Margherita; Domenichini, Alice; Guzzardo, Vincenza; Töchterle, Sonja; et al. (2016). A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-02，引用时请注意版本时效。