DNA错配修复缺失赋予涡虫成体干细胞选择性优势

资源简介

DNA错配修复缺失赋予涡虫成体干细胞选择性优势

【数据集背景】

本数据集源站标题为《Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells》。配套论文《Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells》发表于 PLoS ONE（2011），DOI：10.1371/journal.pone.0021808。源站首次发布：2011-07-01。

【数据内容】

源站原始描述：Lynch syndrome (LS) leads to an increased risk of early-onset colorectal and other types of cancer and is caused by germline mutations in DNA mismatch repair (MMR) genes. Loss of MMR function results in a mutator phenotype that likely underlies its role in tumorigenesis. However, loss of MMR also results in the elimination of a DNA damage-induced checkpoint/apoptosis activation barrier that may allow damaged cells to grow unchecked. A fundamental question is whether loss of MMR provides pre-canc…

【数据结构与技术规格】

文件数 2 个，合计 865.13 KB。Figure_S1.tif：image/tiff，313.07 KB。Figure_S2.tif：image/tiff，552.05 KB。数据集 DOI：10.1371/journal.pone.0021808。

【主题与分类】

源站学科分类：Molecular Biology、Cell Biology。主题标签：dna、mismatch、imparts、selective、planarian、cells。

【适用方向】

源站学科分类标注为 Molecular Biology、Cell Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Loss_of_DNA_Mismatch_Repair_Imparts_a_Selective_Advantage_in_Planarian_Adult_Stem_Cells/135439

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：P. Hollenbach, Jessica; M. Resch, Alissa; Palakodeti, Dasaradhi; R. Graveley, Brenton; D. Heinen, Christopher (2016). Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-05，引用时请注意版本时效。