DataSheet_2: 中国粘液性肺腺癌全外显子测序揭示与肺腺癌不同的特定遗传变异
包含96例中国粘液性肺腺癌患者的全外显子测序数据，用于分析基因组变异和免疫特征。
基本信息
资源简介
DataSheet_2: 中国粘液性肺腺癌全外显子测序揭示与肺腺癌不同的特定遗传变异
【一句话概览】
本数据集是 figshare 公开的组学数据集，收录 1 个文件、合计 33.79 KB，主题涵盖 whole exome sequencing、mucinous pulmonary adenocarcinoma、genomics、immunological features、therapeutics，可用于生物标志物发现与分子分型研究，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinoma.doc》。配套论文《Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung》发表于 Journal of Thoracic Oncology（2015），DOI：10.1097/JTO.0000000000000579。源站首次发布：2022-12-15。
【数据内容】
源站原始描述：BackgroundAs a rare subtype of primary lung adenocarcinoma (LUAD), mucinous pulmonary adenocarcinoma (MPA) was considered a distinctive entity with unfavorable outcomes. Therefore, there is a great need for a better understanding of the genomic and immunological landscape of this rare tumor type, which would inform improved therapeutic strategies. MethodsA total of 96 patients histologically confirmed with MPA were recruited from Shandong Cancer Hospital and Institute (SCH). Single nucleotide va…
【数据结构与技术规格】
文件数 1 个，合计 33.79 KB。DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinom.doc：application/msword，33.79 KB。数据集 DOI：10.3389/fonc.2022.1054845.s002。
【主题与分类】
源站学科分类：Cancer、Haematological Tumours、Molecular Targets、Radiation Therapy、Oncology and Carcinogenesis not elsewhere classified、Solid Tumours。主题标签：whole exome sequencing、mucinous pulmonary adenocarcinoma、genomics、immunological features、therapeutics。
【适用方向】
组学数据适用于生物标志物发现与分子分型相关建模研究。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Whole_exome_sequencing_in_Chinese_mucinous_pulmonary_adenocarcinoma_uncovers_specific_genetic_variations_different_from_lung_adenocarcinoma_doc/21730775
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Zhang, Chenyue; Wang, Kai; Liu, Wenjie; Lin, Jiamao; Li, Zhenxiang; Wang, Hui; et al. (2022). DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinoma.doc. Frontiers. Dataset
【使用注意】
· 源站最后修改于 2023-06-21，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinoma.doc
- DOI：10.3389/fonc.2022.1054845.s002
- 发布日期：2022-12-15
- 文件数：1 个
- 文件总体积：33.79 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Whole_exome_sequencing_in_Chinese_mucinous_pulmonary_adenocarcinoma_uncovers_specific_genetic_variations_different_from_lung_adenocarcinoma_doc/21730775
命令行下载
curl -L -o "DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinom.doc" "https://ndownloader.figshare.com/files/38556266"
文件清单
DataSheet_2_Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinom.doc（33.79 KB）
文件总体积 33.79 KB（源站 API 实测）。
数据说明
BackgroundAs a rare subtype of primary lung adenocarcinoma (LUAD), mucinous pulmonary adenocarcinoma (MPA) was considered a distinctive entity with unfavorable outcomes. Therefore, there is a great need for a better understanding of the genomic and immunological landscape of this rare tumor type, which would inform improved therapeutic strategies.
MethodsA total of 96 patients histologically confirmed with MPA were recruited from Shandong Cancer Hospital and Institute (SCH). Single nucleotide variation (SNV), copy number variation (CNV), genomic instability, and immunological landscape insights into 96 MPA patients were identified using WES.
ResultsWe demonstrated that MPAs had marked different genomic alterations and were more complex in genomic profiles than LUADs. Mutations in Tumor Protein 53 (TP53) and CYP7A Promoter-Binding Factor (CPF) pathways significantly shortened survival whereas mutations in Notch and Wnt pathways significantly prolonged survival in MPA. Besides, we demonstrated that mutations in immune-related genes influenced outcomes, with mutations in TP53, Ataxia Telangiectasia Mutated (ATM), Polymerase (DNA) Delta 1 (POLD1), and Epidermal Growth Factor Receptor (EGFR) correlated with worsened survival.
ConclusionsWe not only depicted the genetic and immunologic landscape of Chinese MPA but also reveal its distinction from LUAD in genomic and immune context. Our findings may provide opportunities for therapeutic susceptibility among Chinese MPA patients.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fonc.2022.1054845.s002（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Whole_exome_sequencing_in_Chinese_mucinous_pulmonary_adenocarcinoma_uncovers_specific_genetic_variations_different_from_lung_adenocarcinoma_doc/21730775）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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