过饱和磷酸钙漱口液预防接受自体或供体干细胞移植的年轻患者口腔黏膜炎

该数据集来自 clinicaltrials.gov,聚焦于接受自体或供体造血干细胞移植的年轻患者,涵盖儿童急性淋巴细胞白血病缓解期、儿童急性髓系白血病缓解期、儿童慢性粒细胞白血病、儿童骨髓增生异常综合征、慢性嗜酸性白血病、慢性粒单核细胞白血病、慢性中性粒细胞白血病及新发骨髓增生异常综合征等病种

Children's Oncology GroupChildren's Oncology Group
clinicaltrials
浏览 4
文本预测Childhood Chronic Myelogenous LeukemiaChildhood Myelodysplastic SyndromesChronic Eosinophilic LeukemiaChronic Myelomonocytic LeukemiaChronic Neutrophilic Leukemiade Novo Myelodysplastic SyndromesDisseminated NeuroblastomaJuvenile Myelomonocytic LeukemiaMucositisRecurrent Childhood Large Cell LymphomaRecurrent Childhood RhabdomyosarcomaRelapsing Chronic Myelogenous Leukemia
Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant

基本信息

模态
文本
任务类型
预测
创建/更新时间
2026-10-12

资源简介

过饱和磷酸钙漱口液预防接受自体或供体干细胞移植的年轻患者口腔黏膜炎

该数据集来自 clinicaltrials.gov,聚焦于接受自体或供体造血干细胞移植的年轻患者,涵盖儿童急性淋巴细胞白血病缓解期、儿童急性髓系白血病缓解期、儿童慢性粒细胞白血病、儿童骨髓增生异常综合征、慢性嗜酸性白血病、慢性粒单核细胞白血病、慢性中性粒细胞白血病及新发骨髓增生异常综合征等病种。数据可用于评估在预处理开始时每日四次口服过饱和磷酸钙漱口液(Caphosol)对比安慰剂,能否降低严重口腔黏膜炎(WHO 3 或 4 级)的持续时间与发生率,属于肿瘤支持治疗领域的干预性研究数据(来源 clinicaltrials.gov)。

【数据内容】

源站描述(机器翻译,仅供参考):条件:儿童急性淋巴细胞白血病缓解期、儿童急性髓系白血病缓解期、儿童慢性粒细胞白血病、儿童骨髓增生异常综合征、慢性嗜酸性白血病、慢性粒单核细胞白血病、慢性中性粒细胞白血病、新发骨髓增生异常综合征。主要目标:I. 确定在造血干细胞移植(HSCT)预处理开始时,局部给予过饱和磷酸钙(Caphosol),每日四次口服漱口,与安慰剂相比,是否通过减少严重口腔黏膜炎(世界卫生组织[WHO] 3 级或 4 级)的持续时间来减轻口腔黏膜炎。次要目标:I. 确定与安慰剂相比,Caphosol 给药是否通过减少严重口腔黏膜炎(WHO 分级

【主题与分类】

主题标签:Childhood Chronic Myelogenous Leukemia、Childhood Myelodysplastic Syndromes、Chronic Eosinophilic Leukemia、Chronic Myelomonocytic Leukemia、Chronic Neutrophilic Leukemia、de Novo Myelodysplastic Syndromes、Disseminated Neuroblastoma、Juvenile Myelomonocytic Leukemia、Mucositis、Recurrent Childhood Large Cell Lymphoma。本站分类:肿瘤/白血病。

【获取与许可】

源站页面:https://clinicaltrials.gov/study/NCT01305200

官方服务

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下载信息

注册下载

需要注册 Kaggle 账号并登录后下载,适合需要跟踪下载记录和使用 API 的用户。

暂未开放

公开下载

无需注册即可直接获取公开样本或文档,适合快速预览和评估数据集质量。

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有偿下载

公开数据集受托下载与技术交付服务。

提供高速下载与技术交付服务(收技术服务费,非数据销售)

暂未开放

当前数据集主要来源为 Kaggle 公开托管,完整影像包建议通过原始链接或 Kaggle API 获取。

使用方式

数据集获取

源站:https://clinicaltrials.gov/study/NCT01305200

标准获取流程:

  1. 访问源站链接,注册/登录账号;
  2. 进入数据集详情页,按页面指引申请权限或直接下载;
  3. 部分平台提供 SDK,例如:
    • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
    • ModelScope: pip install modelscope 后 modelscope download
    • 天池: 登录后页面提供直链下载
      以源站「数据下载/使用文档」页面为准。

数据说明

Conditions: Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Childhood Chronic Myelogenous Leukemia, Childhood Myelodysplastic Syndromes, Chronic Eosinophilic Leukemia, Chronic Myelomonocytic Leukemia, Chronic Neutrophilic Leukemia, de Novo Myelodysplastic Syndromes. PRIMARY OBJECTIVES: I. To determine if topically administered supersaturated calcium phosphate (Caphosol), rinsed orally four times daily at the initiation of conditioning for hematopoietic stem cell transplantation (HSCT), reduces oral mucositis as demonstrated by a decrease in duration of severe oral mucositis (World Health Organization [WHO] grade 3 or 4), compared to placebo. SECONDARY OBJECTIVES: I. To determine whether Caphosol administration, when compared to placebo, reduces oral mucositis as demonstrated by a decrease in incidence of severe oral mucositis (WHO grade 3 or 4); severity of mucositis according to mouth pain categorical rating scale and Oral Mucositis Daily Questionnaire (OMDQ); incidence, total dose, and duration of parenteral opioid analgesic use (morphine equivalents); and incidence and duration of total parenteral nutrition (TPN) administration. II. To determine whether Caphosol administration, when compared to placebo, reduces the incidence of febrile neutropenia and invasive bacterial infections. III. To validate a new pediatric measure of oral mucositis termed the Children’s International Mucositis Evaluation Scale (ChIMES). OUTLINE: This is a multicenter study. Patients are stratified according to conditioning regimen (total-body irradiation (TBI) or melphalan vs neither TBI nor melphalan) and hematopoietic stem cell transplantation (HSCT) (autologous vs allogeneic). Patients are randomized to 1 of 2 treatment arms. ARM I: Patients rinse and gargle with supersaturated calcium phosphate rinse over 1 minute four* times daily (QID) beginning on the first day (about day -7) of the conditioning regimen. ARM II: Patients rinse and gargle with placebo over 1 minute QID* beginning the first day (about day -7) of the conditioning regimen. NOTE: * Patients who reach WHO grade 3 or 4 mucositis have the option to request a total of

数据加载示例(图像类)

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

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