碘131单克隆抗体BC8、磷酸氟达拉滨、环磷酰胺、全身照射及供者骨髓移植治疗晚期急性髓系白血病、急性淋巴细胞白血病或高危骨髓增生异常综合征
该数据集来自clinicaltrials.gov,聚焦于晚期急性髓系白血病、急性淋巴细胞白血病或高危骨髓增生异常综合征患者

基本信息
资源简介
碘131单克隆抗体BC8、磷酸氟达拉滨、环磷酰胺、全身照射及供者骨髓移植治疗晚期急性髓系白血病、急性淋巴细胞白血病或高危骨髓增生异常综合征
该数据集来自clinicaltrials.gov,聚焦于晚期急性髓系白血病、急性淋巴细胞白血病或高危骨髓增生异常综合征患者。研究方案将碘I 131单克隆抗体BC8与移植前后环磷酰胺、磷酸氟达拉滨、2 Gy全身照射、他克莫司、霉酚酸酯及单倍体相合异基因骨髓移植联合使用,主要目标是估算该联合方案中放射性碘I 131-BC8抗体的最大耐受剂量。数据覆盖多种白血病及骨髓增生异常综合征相关疾病状态,可用于血液肿瘤治疗方案的剂量探索与临床特征分析(来源 clinicaltrials.gov)。
【数据内容】
源站描述(机器翻译,仅供参考):条件:继发于既往骨髓增生异常综合征的急性髓系白血病、缓解期成人急性淋巴细胞白血病、缓解期成人急性髓系白血病、存在CD45阳性肿瘤细胞、慢性粒单核细胞白血病、既往接受过治疗的骨髓增生异常综合征、伴原始细胞增多的难治性贫血、伴环形铁粒幼细胞的难治性贫血。主要目标:I. 在患有晚期急性髓系白血病(AML)、急性淋巴细胞白血病(ALL)或高危骨髓增生异常综合征(MDS)的患者中,估算当碘I 131单克隆抗体BC8(131 I-BC8抗体)与移植前后环磷酰胺(CY)、磷酸氟达拉滨(FLU)、2 Gy全身照射(TBI)、他克莫司、霉酚酸酯(MMF)以及单倍体相合异基因造血骨髓移植联合使用时,通过该抗体递送的辐射的最大耐受剂量。II
【主题与分类】
主题标签:CD45-Positive Neoplastic Cells Present、Chronic Myelomonocytic Leukemia、Refractory Anemia With Excess Blasts、Refractory Anemia With Ring Sideroblasts。本站分类:肿瘤/白血病。
【获取与许可】
源站页面:https://clinicaltrials.gov/study/NCT00589316
下载信息
注册下载
需要注册 Kaggle 账号并登录后下载,适合需要跟踪下载记录和使用 API 的用户。
暂未开放公开下载
无需注册即可直接获取公开样本或文档,适合快速预览和评估数据集质量。
免登录有偿下载
公开数据集受托下载与技术交付服务。
提供高速下载与技术交付服务(收技术服务费,非数据销售)
暂未开放当前数据集主要来源为 Kaggle 公开托管,完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取
源站:https://clinicaltrials.gov/study/NCT00589316
标准获取流程:
- 访问源站链接,注册/登录账号;
- 进入数据集详情页,按页面指引申请权限或直接下载;
- 部分平台提供 SDK,例如:
- OpenDataLab:
pip install openxlab后openxlab.dataset.get(...) - ModelScope:
pip install modelscope后modelscope download - 天池: 登录后页面提供直链下载
以源站「数据下载/使用文档」页面为准。
- OpenDataLab:
数据说明
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, CD45-Positive Neoplastic Cells Present, Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts, Refractory Anemia With Ring Sideroblasts. PRIMARY OBJECTIVES: I. To estimate the maximum tolerated dose of radiation delivered via 131 I-BC8 antibody (iodine I 131 monoclonal antibody BC8) when combined with pre- and post-transplant cyclophosphamide (CY), fludarabine phosphate (FLU), 2 Gy total-body irradiation (TBI), tacrolimus, mycophenolate mofetil (MMF), and a haploidentical allogeneic hematopoietic marrow transplant in patients who have advanced acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or high risk myelodysplastic syndromes (MDS). II. To estimate rates of immune reconstitution, engraftment, and donor chimerism resulting from this combined preparative regimen. III. To determine rates of disease relapse, acute graft-versus-host disease (GVHD), and day 100 disease-free survival in patients receiving 131 I-BC8 antibody (Ab) combined with CY, FLU, 2 Gy TBI, tacrolimus, MMF, and human leukocyte antigen (HLA)-haploidentical allogeneic hematopoietic cell transplant (HCT). OUTLINE: This is a dose-escalation study of iodine I 131 monoclonal antibody BC8. RADIOIMMUNOTHERAPY: Patients receive therapeutic iodine I 131 monoclonal antibody BC8 via central line on day -14. NONMYELOABLATIVE CONDITIONING: Patients receive FLU intravenously (IV) over 30 minutes on days -6 to -2 and CY IV over 1 hour on days -6 and -5. Patients undergo TBI on day -1. TRANSPLANTATION: Patients undergo allogeneic bone marrow transplantation on day 0. POST-TRANSPLATATION IMMUNOSUPPRESSION: Patients receive CY IV over 1-2 hours on day 3, MMF IV or orally (PO) thrice daily (TID) on days 4 to 35, and tacrolimus IV over 1-2 hours or PO on days 4 to 180 with taper on day 84. Treatment continues in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 6, 9, 12, 18, and 24 months, an
数据加载示例(图像类)
from PIL import Image
import glob, os
files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)
# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path) # 要求 子目录=类别
目录组织与标注格式以源站说明和下载后实际文件为准。
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