表2_失巢凋亡通路在肾透明细胞癌中的作用及治疗意义.xlsx
一个关于失巢凋亡通路在肾透明细胞癌中作用及治疗意义的Excel表格数据集，包含相关基因、预后模型、药物与免疫治疗分析结果。
基本信息
资源简介
表2_失巢凋亡通路在肾透明细胞癌中的作用及治疗意义.xlsx
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 1 个文件、合计 97.99 KB，主题涵盖 KIRC、anoikis、bioinformatics analysis、cell death、target therapy，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx》。源站首次发布：2022-09-29。
【数据内容】
源站原始描述：Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patie…
【数据结构与技术规格】
文件数 1 个，合计 97.99 KB。Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，97.99 KB。数据集 DOI：10.3389/fonc.2022.1009984.s003。
【主题与分类】
源站学科分类：Cancer、Haematological Tumours、Molecular Targets、Radiation Therapy、Oncology and Carcinogenesis not elsewhere classified、Solid Tumours。主题标签：KIRC、anoikis、bioinformatics analysis、cell death、target therapy。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/Table_2_The_role_and_therapeutic_significance_of_the_anoikis_pathway_in_renal_clear_cell_carcinoma_xlsx/21227378
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Wang, Jin; Qi, Xiaochen; Wang, Qifei; Wu, Guangzhen (2022). Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx. Frontiers. Dataset
【使用注意】
· 源站最后修改于 2023-06-16，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx
- DOI：10.3389/fonc.2022.1009984.s003
- 发布日期：2022-09-29
- 文件数：1 个
- 文件总体积：97.99 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_2_The_role_and_therapeutic_significance_of_the_anoikis_pathway_in_renal_clear_cell_carcinoma_xlsx/21227378
命令行下载
curl -L -o "Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx" "https://ndownloader.figshare.com/files/37648238"
文件清单
Table_2_The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma.xlsx（97.99 KB）
文件总体积 97.99 KB（源站 API 实测）。
数据说明
Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patients with KIRC, we investigated several genes of the anoikis pathway most closely related to KIRC and also contrasted the effects of common anticancer drugs on the KIRC pathway. Besides KIRC, we explored the expression of anoikis-related genes in various other cancers. We classified patients with KIRC into three clusters based on the coefficients and mRNA expression levels of anoikis-related genes selected using the GSVA algorithm. We used the GDSC database to predict the response of the anoikis pathway to common anticancer drugs and explored the potential targets of the anoikis pathway in KIRC. We then analyzed the response of common immunotherapies to the anoikis pathway to analyze the correlation between anoikis and immune checkpoint inhibitor therapy. Finally, eleven cancer-related genes were screened and a prognostic model was constructed using LASSO regression.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fonc.2022.1009984.s003（source: https://frontiersin.figshare.com/articles/dataset/Table_2_The_role_and_therapeutic_significance_of_the_anoikis_pathway_in_renal_clear_cell_carcinoma_xlsx/21227378）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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