数据表1：中国透明细胞肾细胞癌患者综合基因组图谱

数据集获取（Figshare）

• 源站标题：DataSheet_1_Comprehensive Genomic Landscape in Chinese Clear Cell Renal Cell Carcinoma Patients.docx
• DOI：10.3389/fonc.2021.697219.s001
• 发布日期：2021-09-09
• 文件数：1 个
• 文件总体积：423.98 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Comprehensive_Genomic_Landscape_in_Chinese_Clear_Cell_Renal_Cell_Carcinoma_Patients_docx/16594964

命令行下载

curl -L -o "DataSheet_1_Comprehensive Genomic Landscape in Chinese Clear Cell Renal Cell Carcinoma Patients.docx" "https://ndownloader.figshare.com/files/30717974"

文件清单

• DataSheet_1_Comprehensive Genomic Landscape in Chinese Clear Cell Renal Cell Carcinoma Patients.docx（423.98 KB）

文件总体积 423.98 KB（源站 API 实测）。

数据说明

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC). The genomic landscape in Chinese ccRCC needs to be elucidated. Herein, we investigated the molecular features of Chinese ccRCC patients. Genomic profiling of DNA was performed through next-generation sequencing (NGS) in Chinese patients with ccRCC between January 2017 and March 2020. Clinical information including age, gender, and tumor histology was collected. Immunohistochemistry (IHC) staining for PD-L1 expression was performed using PD-L1 IHC 22C3 pharmDx assay or Ventana PD-L1 SP263 assay. Data analyses were performed using R 3.6.1. A total of 880 Chinese ccRCC patients who have undergone NGS were included in this study. The most common somatic alterations were detected in VHL (59.7%), PBRM1 (18.0%), SETD2 (12.2%), BAP1 (10.2%), and TP53 (9.4%). Compared with The Cancer Genome Atlas (TCGA) database, a higher mutation frequency of VHL (59.7% vs. 50.0%, p < 0.001) and TP53 (9.4% vs. 3.5%, p < 0.001) and a lower mutation frequency of PBRM1 (18.0% vs. 31.0%, p < 0.001) were found in the Chinese cohort. Of the 460 patients who were evaluated for PD-L1 expression, 139 (30.2%) had positive PD-L1 expression. The median tumor mutational burden (TMB) value was 4.5 muts/Mb (range, 0–46.0). Five (0.7%) patients were identified as microsatellite instability-high (MSI-H). Furthermore, 52 (5.9%) patients were identified to carry pathogenic or likely pathogenic germline mutations in 22 cancer predisposition genes. This is the first large-scale comprehensive genomic analysis for Chinese ccRCC patients, and these results might provide a better understanding of molecular features in Chinese ccRCC patients, which can lead to an improvement in the personalized treatment for these patients.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fonc.2021.697219.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Comprehensive_Genomic_Landscape_in_Chinese_Clear_Cell_Renal_Cell_Carcinoma_Patients_docx/16594964）。